Author

S. Balint

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Assay:flow cytometry· 1

Frequent Co-Authors

M. Dustin· 4 shared M. L. Dustin· 2 shared O. Dushek· 2 shared V. Mayya· 2 shared A. Alrubayyi· 1 shared A. C. Kalli· 1 shared A. Clarke· 1 shared A. Cohnen· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

M. Dustin

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis

J. Ogbechi, H. L. Wright, S. Balint, L. Topping, K. Zec, I.-S. Huang, E. Pantazi, M. Swart, D. Windell, E. Marin, M. F. Wempe, H. Endou, A. M. Thomas, A. Filer, T. W. Stone, , R. Williams

This study shows LAT1 is critical for T cell activation in rheumatoid arthritis and identifies it as a therapeutic target, with a LAT1 inhibitor effective in mouse models.

bioRxiv · Dec 20, 2022 · PreprintImmunology

Coordination of KIF3A and KIF13A regulates leading edge localization of MT1-MMP in cancer cells

V. Gifford, A. M. Woskowicz, N. Ito, S. Balint, M. Dustin, Y. Itoh

The paper identifies KIF3A and KIF13A coordination in transporting MT1-MMP vesicles to the leading edge, inhibiting cancer cell invasion when knocked down.

bioRxiv · May 24, 2021 · PreprintCell Biology

Allosteric activation of T-cell antigen receptor signalling by quaternary structure relaxation

A.-L. Lanz, G. Masi, N. Porciello, A. Cohnen, D. Cipria, D. Prakaash, S. Balint, R. Raggiaschi, D. Galgano, D. Cole, M. Lepore, O. Dushek, M. Dustin, M. Sansom, A. C. Kalli, O. Acuto

This study identifies mutations that enhance TCR-CD3 signalling by loosening TCR{beta} and CD3{zeta} interactions, showing pMHC binding can induce allosteric changes and initiate signal propagation.

bioRxiv · Dec 2, 2020Immunology

IL-15 re-programming compensates for NK cell mitochondrial dysfunction in HIV-1 infection

E. Moreno Cubero, S. Balint, A. Alrubayyi, A. Ogbe, R. Matthews, F. Burns, S. Rowland Jones, P. Borrow, A. Schurich, M. Dustin, D. Peppa

This study shows that IL-15 treatment improves NK cell function in HIV-1 infection by enhancing mTORC1 activity and compensating for mitochondrial dysfunction.

bioRxiv · Oct 21, 2019 · PreprintImmunology

A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells

E. Abu-Shah, P. Demetriou, S. Balint, V. Mayya, M. A. Kutuzov, O. Dushek, M. L. Dustin

This paper develops a tissue-like platform to study interactions between engineered quiescent human T-cells and dendritic cells, demonstrating CD4 help and PD-1 checkpoint blockade effects.

bioRxiv · Sep 12, 2019Immunology

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T-cells

D. G. Saliba, P. F. Cespedes-Donoso, S. Balint, E. B. Compeer, S. Valvo, K. Korobchevskaya, V. Mayya, Y. Peng, T. Dong, M.-L. Tognoli, E. O Neill, S. Bonham, R. Fischer, B. M. Kessler, M. L. Dustin

The paper identifies synaptic ectosomes released by helper T cells that contain TCR and CD40L, enabling dendritic cell maturation and cytokine production.

bioRxiv · Apr 9, 2019Immunology