ImmunologybioRxiv
Allosteric activation of T-cell antigen receptor signalling by quaternary structure relaxation
A.-L. Lanz, G. Masi, N. Porciello…·O. Acuto
This study identifies mutations that enhance TCR-CD3 signalling by loosening TCR{beta} and CD3{zeta} interactions, showing pMHC binding can induce allosteric changes and initiate signal propagation.
DOI 10.1016/j.celrep.2021.109375