Author

D. R. Croucher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Burgess· 2 shared A. Gonzalez-Rajal· 2 shared A. L. Cadell· 2 shared D. N. Watkins· 2 shared J. F. Hastings· 2 shared P. D. Mace· 2 shared R. A. McCloy· 2 shared V. Chin· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

A. Burgess

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Author profile →

5 papers

Recent·Most cited

Bisphosphonate drugs have actions outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages

M. J. Rogers, M. A. Munoz, E. K. Fletcher, O. P. Skinner, J. Jurczyluk, E. Kristianto, M. Hodson, S. Sun, F. H. Ebetino, D. R. Croucher, P. M. Hansbro, J. R. Center

This study shows bisphosphonates inhibit the mevalonate pathway in macrophages, enhancing immune responses to bacterial endotoxin in the lung.

eLife · Dec 30, 2021Peer-reviewedPharmacology & Toxicology

A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma

A. Gonzalez-Rajal, K. Marzec, R. A. McCloy, M. Nobis, V. Chin, J. F. Hastings, K. Lai, M. Kennerson, W. E. Hughes, V. Vaghjiani, P. Timpson, J. Cain, D. N. Watkins, D. R. Croucher, A. Burgess

The paper identifies a non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma, showing that early S phase cells maintain proliferative capacity with reduced DNA damage.

bioRxiv · Nov 26, 2020 · PreprintCell Biology

A cryptic tubulin-binding domain links MEKK1 to microtubule remodelling

P. Filipcik, S. L. Latham, A. L. Cadell, C. L. Day, D. R. Croucher, P. D. Mace

This paper identifies a previously unknown TOG domain in MEKK1 that binds curved tubulin heterodimers, and shows mutations disrupting this interaction are enriched in tumors.

bioRxiv · Apr 7, 2020 · PreprintBiochemistry

Dynamic analysis of pulsed cisplatin identifies effectors of resistance in lung adenocarcinoma

J. F. Hastings, A. Gonzalez-Rajal, J. Z. Han, R. A. McCloy, Y. E. O'Donnell, M. Phimmachanh, A. D. Murphy, A. Nagrial, D. Daneshvar, V. Chin, D. N. Watkins, A. Burgess, D. R. Croucher

This study identifies P70S6K as a mediator of cisplatin resistance in lung adenocarcinoma using in vitro assays mimicking in vivo pharmacokinetics.

bioRxiv · Sep 20, 2019Cancer Biology

Mechanism of preferential complex formation by Apoptosis Signal-regulating Kinases

S. J. Trevelyan, J. L. Brewster, A. E. Burgess, J. M. Crowther, A. L. Cadell, B. L. Parker, D. R. Croucher, R. C. Dobson, J. M. Murphy, P. D. Mace

This study identifies the mechanism by which ASK1-3 kinases form preferential heterocomplexes through their SAM domains, revealing structural insights into their role in inflammatory signaling.

bioRxiv · Jul 5, 2019Biochemistry