Author

J. Cain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Budina· 1 shared A. Burgess· 1 shared A. Gonzalez-Rajal· 1 shared A. K. Godwin· 1 shared A. Kovacs· 1 shared A. M. Douglas· 1 shared A. Mannan· 1 shared A. Rickel· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Budina

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

R. J. Duchatel, E. R. Jackson, S. G. Parackal, C. Sun, P. Daniel, A. Mannan, I. J. Findlay, D. Staudt, Z. P. Germon, S. Laternser, D. Kiltschewskij, P. S. Kearney, M. F. B. Jamaluddin, A. M. Douglas, T. Beitaki, , M. D. Dun

This study identifies PI3K/mTOR as a targetable genetic dependency in DIPG and demonstrates that combining paxalisib with metformin improves survival in xenograft models.

bioRxiv · Apr 17, 2023Cancer Biology

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum

C.-L. Lu, S. Ortmeier, J. Brudvig, T. Moretti, J. Cain, S. Boyadjiev, J. M. Weimer, J. Kim

The paper shows SEC24D is critical for collagen secretion, while other SEC24 paralogs also contribute, explaining tissue-specific phenotypes in SEC24 mutations.

bioRxiv · Feb 23, 2021Cell Biology

A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma

A. Gonzalez-Rajal, K. Marzec, R. A. McCloy, M. Nobis, V. Chin, J. F. Hastings, K. Lai, M. Kennerson, W. E. Hughes, V. Vaghjiani, P. Timpson, J. Cain, D. N. Watkins, D. R. Croucher, A. Burgess

The paper identifies a non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma, showing that early S phase cells maintain proliferative capacity with reduced DNA damage.

bioRxiv · Nov 26, 2020 · PreprintCell Biology

Tumor-infiltrating nerves create an electro-physiologically active microenvironment and contribute to treatment resistance

A. Kovacs, D. W. Vermeer, M. Madeo, H. Reavis, S. J. Vermeer, C. S. Williamson, A. Rickel, J. Stamp, C. T. Lucido, J. Cain, M. Bell, M. Morgan, J.-Y. Yoon, M. A. Mitchell, N. Tulina, , P. D. Vermeer

The paper shows that tumor-infiltrating nerves contribute to treatment resistance and that chemotherapy increases tumor innervation.

bioRxiv · Apr 24, 2020Cancer Biology