Author

K. Lai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 2 Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:differential expression· 5 Research Focus:cell type annotation· 4 Approach:statistical model· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:gene regulatory network inference· 3 Assay:proteomics· 3

Frequent Co-Authors

W. Li· 3 shared C. Yang· 2 shared J. Tu· 2 shared J. Zou· 2 shared Q. Yan· 2 shared S. Yang· 2 shared W. Ding· 2 shared X. Bai· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCell Biology

W. Li

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Un1Cas12f1 and Cas9 gene drive in HSV1: Viruses that 'infect' viruses

Q. Yao, Z. Lin, K. Lai, X. Zeng, G. Lei, T. Zhang, H. Dai

This study develops Cas9 and Un1Cas12f1 gene drives in HSV1 to assess gene drive efficacy and resistance, finding Un1Cas12f1 has higher conversion and lower resistance.

bioRxiv · Dec 4, 2023Microbiology

Cellular protein painting for structural and binding sites analysis via lysine reactivity profiling with o-phthalaldehyde

Z. Zheng, Y. Zeng, K. Lai, B. Liao, P. Li, C. S. H. Tan

This paper introduces RAPID-OPA, a method for intracellular protein labeling and structural analysis, identifying ligand-binding sites and conformational changes in cells.

bioRxiv · Sep 8, 2023 · PreprintCell Biology

Disease-associated gut microbiome and metabolome changes in chronic low back pain patients with bone marrow lesions

W. Li, J. Tu, J. Zheng, A. Das, Q. Yan, X. Jiang, W. Ding, X. Bai, K. Lai, S. Yang, C. Yang, J. Zou, A. D. Diwan, Z. Zheng

This study examines gut microbiome and serum metabolome changes in chronic low back pain patients with bone marrow lesions, identifying key microbial species and metabolic pathways involved.

bioRxiv · Jul 26, 2023 · PreprintCell Biology

Discovery of microsized RNA-derived RNAs and polypeptides in human cells

X. Huang, H. Wu, W. Zhong, W. Li, Z. Liu, Z. Yang, M. Zhao, X. Xi, B. Cao, Y. Pu, X. Kong, H. Zhao, R. Zhang, K. Lai, X. Lv, , S. Chen

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

bioRxiv · Apr 24, 2023 · PreprintBiochemistry

Single-cell transcriptome profiling reveals multicellular ecosystem of nucleus pulposus during degeneration progression

J. Tu, W. Li, S. Yang, P. Yang, Q. Yan, S. Wang, K. Lai, X. Bai, C. Wu, W. Ding, J. Cooper-White, A. Diwan, C. Yang, H. Yang, J. Zou

This study uses single-cell transcriptomics to identify novel cell populations and functional differences in human nucleus pulposus during degeneration, revealing potential regenerative and immunosuppressive roles.

bioRxiv · May 25, 2021Cell Biology

Modulation of SARS-CoV-2 Spike-induced Unfolded Protein Response (UPR) in HEK293T cells by selected small chemical molecules

B. Balakrishnan, K. Lai

The paper investigates how selected small molecules modulate the UPR in HEK293T cells overexpressing SARS-CoV-2 Spike protein, finding that PBA and TUDCA reduce peIF2 and autophagy levels.

bioRxiv · Feb 4, 2021 · PreprintBiochemistry

A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma

A. Gonzalez-Rajal, K. Marzec, R. A. McCloy, M. Nobis, V. Chin, J. F. Hastings, K. Lai, M. Kennerson, W. E. Hughes, V. Vaghjiani, P. Timpson, J. Cain, D. N. Watkins, D. R. Croucher, A. Burgess

The paper identifies a non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma, showing that early S phase cells maintain proliferative capacity with reduced DNA damage.

bioRxiv · Nov 26, 2020 · PreprintCell Biology

Organoid Polymer Functionality and Mode of Klebsiella Pneumoniae Membrane Antigen Presentation Regulates Ex Vivo Germinal Center Epigenetics in Young and Aged B Cells

P. L. Graney, K. Lai, S. Post, I. Brito, J. Cyster, A. Singh

The paper develops PEG-organoids to study how polymer chemistry and antigen presentation affect germinal center-like B cell epigenetics in young and aged mice.

bioRxiv · Feb 16, 2020Immunology

Estimation of Pharmacokinetic Parameters of Continuous Intravenous Flucloxacillin infusion in the Outpatient Settings (PKFLUCLOX)

N. Lwin, Z. Liu, M. Loewenthal, P. Dobson, J. W. Yoo, P. Galettis, K. Lai, J. Martin

This study characterizes the pharmacokinetics of flucloxacillin in outpatient continuous infusion using population analysis and identifies CrCL as the best covariate for clearance.

bioRxiv · Dec 19, 2018 · PreprintPharmacology & Toxicology