D. R. Valenzano

This study identifies age-related inflammation and genome instability in the immune niche of turquoise killifish using single-cell RNA sequencing and proteomics.

This study examines how population size affects lifespan evolution under mutation accumulation and antagonistic pleiotropy, finding that larger populations reduce mortality and can extend lifespan.

This study examines age-related loss of antibody diversity in turquoise killifish, showing rapid decline in whole-body and intestinal repertoires with age.

The study uses genomic data from Seychelles killifish to support trans-oceanic colonization and identifies relaxed selection on developmental genes.

This study investigates how population size differences among turquoise killifish populations affect lifespan and genome evolution, finding that small populations accumulate deleterious mutations linked to short lifespan.

This study examines the genomic structure and evolution of the immunoglobulin heavy chain locus in teleost fishes, revealing extreme volatility through duplication and deletion events in the IGHZ gene.

AEGIS models genome evolution in age-structured populations, showing ageing-like phenotypes emerge in stable environments and sexual reproduction enhances beneficial mutation accumulation.