Author

D. Renner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

L. H. Tan· 2 shared N. Cohen· 2 shared S. R. Weiss· 2 shared A. Fehr· 1 shared B. Dong· 1 shared C. Comar· 1 shared C. E. Comar· 1 shared C. Otter· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

L. H. Tan

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2 papers

Recent·Most cited

MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells

C. Comar, C. Otter, J. Pfannenstiel, E. Doerger, D. Renner, L. H. Tan, S. Perlman, N. Cohen, A. Fehr, S. R. Weiss

This study shows that MERS-CoV's EndoU and accessory proteins NS4a/NS4b together suppress innate immunity, enabling viral replication, unlike SARS-CoV-2 which activates these pathways.

bioRxiv · Dec 20, 2021 · PreprintMicrobiology

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes

Y. Li, D. Renner, C. E. Comar, J. Whelan, H. Reyes, F. L. Cardenas-Diaz, R. Truitt, L. H. Tan, B. Dong, K. D. Alysandratose, J. Huang, J. N. Palmer, N. D. Adappa, M. A. Kohanski, D. N. Kotton, , S. R. Weiss

This study investigates how SARS-CoV-2 interacts with host antiviral pathways in respiratory and cardiac cells, finding it activates OAS-RNase L and PKR but not IFN, contrasting with MERS-CoV.

bioRxiv · Sep 24, 2020Microbiology