Author

A. Fehr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

J. J. Pfannenstiel· 3 shared D. V. Ferraris· 2 shared S. Parthasarathy· 2 shared S. Perlman· 2 shared S. Wazir· 2 shared Y. M. Alhammad· 2 shared A. Ferkul· 1 shared A. Galera-Prat· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

J. J. Pfannenstiel

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

PARP14 is an interferon (IFN)-induced host factor that promotes IFN production and affects the replication of multiple viruses

S. Parthasarathy, P. Saenjamsai, H. Hao, A. Ferkul, J. J. Pfannenstiel, D. S. Bejan, Y. Chen, E. L. Suder, N. Schwarting, M. Aikawa, E. Muhlberger, A. J. Hume, R. C. Orozco, C. S. Sullivan, M. S. Cohen, , A. Fehr

This paper shows PARP14 promotes IFN production and has both antiviral and proviral functions against multiple viruses.

bioRxiv · Apr 26, 2024Microbiology

Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target

S. Wazir, T. A. O. Parviainen, M. M. Maksimainen, M. T. H. Duong, J. J. Pfannenstiel, D. Cluff, S. T. Sowa, A. Galera-Prat, D. V. Ferraris, A. Fehr, J. P. Heiskanen, L. Lehtiö

This paper identifies small molecule inhibitors of SARS-CoV-2 Mac1 that inhibit coronavirus replication, validating Mac1 as an anti-viral target.

bioRxiv · Aug 28, 2023 · PreprintBiochemistry

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

Y. M. Alhammad, S. Parthasarathy, R. Ghimire, J. J. O'Connor, C. M. Kerr, J. J. Pfannenstiel, D. Chanda, C. A. Miller, R. Unckless, S. Zuniga, L. Enjuanes, S. More, R. Channappanavar, A. Fehr

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

bioRxiv · Apr 6, 2023 · PreprintMicrobiology

Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV-2 nsp3 Macrodomain

L. M. Sherrill, E. E. Joya, A. Walker, A. Roy, Y. M. Alhammad, M. Atobatele, S. Wazir, G. Abbas, P. Keane, J. Zhuo, A. Leung, D. K. Johnson, L. Lehtio, A. Fehr, D. V. Ferraris

This study designs and synthesizes inhibitors targeting the SARS-CoV-2 nsp3 macrodomain, identifying compound 15c as a low-micromolar inhibitor with structural and thermal evidence of binding.

bioRxiv · Feb 27, 2022 · PreprintBiochemistry

MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells

C. Comar, C. Otter, J. Pfannenstiel, E. Doerger, D. Renner, L. H. Tan, S. Perlman, N. Cohen, A. Fehr, S. R. Weiss

This study shows that MERS-CoV's EndoU and accessory proteins NS4a/NS4b together suppress innate immunity, enabling viral replication, unlike SARS-CoV-2 which activates these pathways.

bioRxiv · Dec 20, 2021 · PreprintMicrobiology

β-Coronaviruses use lysosomal organelles for cellular egress.

N. Altan-Bonnet, G. Y. Altan-Bonnet, S. Ghosh, T. Dellibovi-Ragheb, E. Pak, Q. Qiu, M. Fisher, P. Takvorian, C. Bleck, V. Hsu, A. Fehr, S. Perlman, M. Straus, G. Whittaker, C. A. de Haan

This study shows β-coronaviruses exit cells via lysosomal trafficking, not the secretory pathway, and identifies Arl8b as a regulator of this process.

bioRxiv · Jul 25, 2020 · PreprintMicrobiology