PhysiologybioRxivPreprint
Inhibition of mammalian mtDNA transcription paradoxically activates liver fatty acid oxidation to reverse diet-induced hepatosteatosis and obesity
S. Jiang, T. Yuan, L. S. Kremer…·N.-G. Larsson
The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.
DOI 10.1101/2023.09.22.558955