Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane Dynamics
T. J. Walker, E. Reyes-Alvarez, B. D. Hyndman…·L. M. Mulligan
This study shows that TMEM127 loss leads to RET receptor accumulation on the cell surface, promoting constitutive signaling and cell proliferation in PCC.