C. M. Lieber

This study identifies mutations conferring resistance to 4-fluorouridine in influenza viruses and shows that resistant variants are attenuated in vivo and can be overcome by higher drug doses.

This paper develops biochemically-functionalized probes that selectively target and record from specific cell types in the brain, demonstrating their effectiveness in vivo.

This study shows that prior respiratory virus infections worsen measles severity in ferrets and that antiviral treatment can mitigate immune amnesia and disease outcomes regardless of treatment timing.

This paper describes an injectable spinal stimulator that enables precise and programmable hindlimb movement in mice by targeting ventral spinal regions.

This paper introduces a flexible probe that can be stitched into multiple brain regions of mice to monitor chronic neuronal activity with high stability and minimal immune response.

This paper develops ultra-flexible endovascular neural probes for brain recording in small blood vessels without damaging tissue, achieving electrophysiology recordings and long-term stability.

This study compares the efficacy of paxlovid and molnupiravir in preventing SARS-CoV-2 transmission in ferrets, finding that molnupiravir reduces transmission while paxlovid does not.

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

This paper describes a method to rapidly design immunostaining protocols for cleared tissue by using tissue libraries, showing that mouse tissue can substitute for human tissue in protocol optimization.

This study evaluates molnupiravir efficacy against SARS-CoV-2 variants in different models, finding VOC-dependent efficacy and sex-based differences in dwarf hamsters.