Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase
D. Scheerer, B. V. Adkar, S. Bhattacharyya, D. Levy, M. Iljina, I. Riven, O. Dym, G. Haran, E. Shakhnovich
This study investigates how AMP substrate inhibition in adenylate kinase is modulated by domain motions, showing that inhibitory concentrations of AMP increase domain closure and affect catalytic activity.
bioRxiv · Nov 21, 2022 · PreprintBiophysics