J. Shin

Explainable Multimodal Prognostic Modeling Uncovers New Clinically Relevant Pathological Features in a Multi-Institutional Pancreatic Neuroendocrine Tumor Cohort

This paper develops a multimodal prognostic model for pancreatic neuroendocrine tumors using clinicopathologic data and histology images, finding that stromal features are as prognostic as tumor cells.

Proteome-wide neuropeptide identification using NeuroPeptide-HMMer (NP-HMMer)

NP-HMMer identifies neuropeptides across diverse species by using HMMs for 46 families, discovering novel peptides in Priapulida and Rotifera.

Loss of asgr1a leads to the secretion of excess dietary cholesterol in zebrafish

This study shows that loss of asgr1a in zebrafish leads to excess dietary cholesterol excretion rather than hepatic accumulation, suggesting a role for ASGR1 in cholesterol metabolism.

ERK3/MAPK6 promotes triple-negative breast cancer progression through collective migration and EMT plasticity

This study shows ERK3 promotes TNBC progression through EMT plasticity and collective migration, linking it to poor clinical outcomes.

TRPV4-Expressing Tissue-Resident Macrophages Regulate the Function of Collecting Lymphatic Vessels via Thromboxane A2 Receptors in Lymphatic Muscle Cells

This study identifies TRPV4-expressing macrophages as regulators of lymphatic vessel function through TXA2 receptors, suggesting therapeutic targets for lymphedema.

Chaperonin-mediated Winter Cold Response via Circadian Clock Components in Arabidopsis

The paper identifies chaperonin's role in regulating circadian clocks to mediate long-term cold responses in Arabidopsis, showing time-of-day-specific activation of cold response genes.

Limosilactobacillus fermentum ATG-V5 stimulates the immune response by enhancing gut microbiome and metabolite in a cyclophosphamide-induced immunosuppression mouse model

This study shows that Limosilactobacillus fermentum ATG-V5 enhances immune response in a cyclophosphamide-induced immunosuppression mouse model by modulating gut microbiota and metabolites.

A FOXA1/SPDEF Co-regulatory Axis Drives ERBB2 and Suppresses TEAD/YAP-Driven EMT to Maintain Luminal Identity in HER2+ Breast Cancer

This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.

Dysfunctional β-cell longevity in diabetes relies on high energy conservation and positive epistasis

The paper identifies PFKFB3-expressing dysfunctional β-cells in T2D, showing their survival via positive epistasis and reduced clearance, and demonstrates PFKFB3 inhibition restores glucose tolerance in mice.

VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1

This study identifies VPS13B's localization at the cis-trans Golgi interface and shows its functional interaction with FAM177A1 in lipid transport and Golgi dynamics.

The biochemical impact of extracting an embedded adenylate kinase domain using circular permutation

This study examines how circular permutation of an adenylate kinase domain affects enzyme activity and stability in mesophilic and thermophilic AKs.

Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology

This paper introduces OT-TP-LSM for 3D pathology, achieving high imaging depths and enabling virtual H&E image generation via deep learning.

Fourth dose of Microneedle Array Patch of SARS-CoV-2 S1 Protein Subunit Vaccine Elicits Robust Long-lasting Humoral Responses in mice

This study evaluates a microneedle array patch-based S1 subunit vaccine in mice, showing that four doses induce robust, long-lasting immune responses against multiple SARS-CoV-2 variants.

Evidence of Disrupted-in Schizophrenia 1 (DISC1) as an arsenic binding protein and implications regarding its role as a translational activator

This study shows DISC1 binds arsenic via a C-terminal cysteine motif and suggests it acts as a sensor and translational modulator in the Akt/mTOR pathway.

Vutiglabridin Alleviates Cellular Senescence Process of Dysfunctional Replication, Metabolic Regulation, and Circadian Clock in Primary Human Dermal Fibroblasts

This study shows that vutiglabridin reduces cellular senescence markers, restores circadian rhythm, and improves mitochondrial function in human dermal fibroblasts.

Metabolic engineering of Saccharomyces cerevisiae for second-generation ethanol production from xylo-oligosaccharides and acetate

This study engineers Saccharomyces cerevisiae to simultaneously ferment xylo-oligosaccharides, xylose, and acetate, producing 60% more ethanol and 12% less xylitol than the control strain.

Keratinocytes coordinate inflammatory responses and regulate development of secondary lymphedema

This study shows keratinocytes drive secondary lymphedema by producing Th2 cytokines and that targeting their activation can reduce inflammation and swelling in mice.

Visualization of a Limonene Synthesis Metabolon inside Living Bacteria by Hyperspectral SRS Microscopy

The paper visualizes limonene synthesis metabolons in engineered E. coli using hyperspectral SRS microscopy and confirms colocalization with limonene synthase.

Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses

This study shows that lymphatic dysfunction in lupus exacerbates cutaneous photosensitivity and lymph node B cell responses, and that improving lymphatic flow reduces these effects.

Long-term label-free assessments of individual bacteria using three-dimensional quantitative phase imaging and hydrogel-based immobilization

This paper introduces a hydrogel-based method for long-term label-free 3D imaging of live bacteria, enabling precise analysis of biophysical parameters and antibiotic responses.

Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFbeta3/TFEB/STAT3 Pathway Early during Mammary Gland Involution

The paper shows that intracellular calcium, triggered by milk stasis, activates STAT3 via SOCS3 degradation and TFEB, leading to lysosome-dependent cell death during mammary gland involution.

Directed Evolution of Aptamer Discovery Technologies

This paper describes four techniques to improve aptamer discovery, enabling efficient isolation of high-affinity and specific aptamers for challenging targets.

Control of protein activity by photoinduced spin polarized charge reorganization

This study demonstrates that photoinduced spin polarized charge reorganization within proteins can modulate enzyme activity and protein-protein interactions.

Non-Gaussian, transiently anomalous and ergodic self-diffusion of flexible dumbbells in crowded two-dimensional environments: coupled translational and rotational motions

This paper studies the diffusion behavior of flexible dumbbells in crowded 2D environments using simulations, finding non-Gaussian and anomalous diffusion regimes and analyzing their dependence on crowding fraction.

Inhibition of Ras1-MAPK pathways for hypha formation by novel drug candidates in Candida albicans

This paper identifies small carbazole derivatives that inhibit C. albicans morphogenesis and pathogenicity by targeting the Ras1/MAPK pathway, showing efficacy in drug-resistant strains and in vivo.

Effect of chronic JUUL aerosol inhalation on inflammatory states of the brain, lung, heart and colon in mice

Chronic JUUL aerosol inhalation in mice alters inflammatory states in brain, lung, heart, and colon, with flavor-dependent effects and potential long-term health risks.

Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy

This study shows that targeting Gpi1 selectively inhibits pathogenic Th17 cells in autoimmune diseases while sparing homeostatic Th17 cells.

Thermal fluctuations assist mechanical signal propagation in coiled-coil proteins

The paper shows thermal fluctuations enable mechanical signal propagation in coiled-coil proteins through numerical simulations of a simplified Frenkel-Kontorova chain model.

Pyrazinamide triggers degradation of its target aspartate decarboxylase

This paper shows that pyrazinamide's active form, POA, triggers degradation of its target enzyme PanD via the ClpC1-ClpP protease, rather than inhibiting it directly.

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

The paper identifies an immunosuppressive microenvironment in human prostate cancer bone metastases and shows that disrupting the CCL20-CCR6 axis can restore T cell reactivity and improve survival in mice.