D. Levy

EARLY NEUTROPHIL ACTIVATION AND NETs RELEASE IN THE PRISTANE-INDUCED LUPUS MICE MODEL

This study shows pristane-induced lupus mice have increased activated neutrophils, LDGs, and NETs compared to controls, suggesting early innate immune activation contributes to lupus development.

SUMO-mediated regulation of a H3K4me3 reader controls germline development in C. elegans

This study identifies ULP-2/SET-26 axis regulation of germline development in C. elegans through SUMO-mediated control of H3K4me3 reader activity.

Conformational changes of the ABC Transporter BmrA Depend on Membrane Curvature

This study shows that the conformational changes of the bacterial ABC transporter BmrA are influenced by membrane curvature, affecting its activity and conformational states.

Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate α

The paper identifies how spatial N-glycan rearrangements on α5β1 integrin nucleate galectin-3 oligomers, determining endocytic fate and retrograde trafficking.

How Myosin VI Traps its Off-State, is Activated and Dimerizes

This study investigates how Myosin VI is trapped in its off-state, activated, and dimerizes through structural and functional analyses of its interactions with partners.

Mesenchymal stem cell culture within perfusion bioreactors incorporating 3D-printed scaffolds enables improved extracellular vesicle yield with preserved bioactivity

This study shows that culturing mesenchymal stem cells in 3D-printed scaffold perfusion bioreactors increases extracellular vesicle production and improves wound healing in diabetic mice.

From Microstates to Macrostates in the Conformational Dynamics of GroEL: a Single-Molecule FRET Study

This study uses single-molecule FRET to analyze conformational dynamics of GroEL subunits, revealing four microstates and their macrostate transitions under different solution conditions.

Induced pluripotent stem cell-derived extracellular vesicles promote wound repair in a diabetic mouse model via an anti-inflammatory immunomodulatory mechanism

This study shows that extracellular vesicles from undifferentiated iPSCs outperform those from iMSCs in promoting wound healing in diabetic mice through anti-inflammatory effects.

Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity

This study evaluates how differentiation state and culture conditions affect the neuroregenerative bioactivity of extracellular vesicles (EVs) from neural stem/progenitor cells (NPSCs).

Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase

This study investigates how AMP substrate inhibition in adenylate kinase is modulated by domain motions, showing that inhibitory concentrations of AMP increase domain closure and affect catalytic activity.

Combinatorial microRNA loading into extracellular vesicles for anti-inflammatory therapy

The paper investigates the anti-inflammatory effects of loading multiple miRNAs into extracellular vesicles and identifies a combination of miR-146a, miR-155, and miR-223 as the most effective.

The Impact of Storage Condition and Duration on Function of Native and Cargo-Loaded Mesenchymal Stromal Cell Extracellular Vesicles

This study evaluates how storage temperature, duration, and lyophilization affect the bioactivity and cargo retention of mesenchymal stromal cell extracellular vesicles.

VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites

This study shows that VAP-A's intrinsically disordered regions enable its versatile localization at different membrane contact sites by adjusting geometry to MCS organization and lifetime.

Structure-function conservation between the methyltransferases SETD3 and SETD6

The paper identifies shared and distinct functions of SETD3 and SETD6 in apoptosis regulation through proteomic and RNA-seq analyses of knockout cells.

PI4P and BLOC-1 remodel endosomal membranes into tubules

This study shows how PI4P and BLOC-1 coordinate to form and stabilize endosomal tubules, essential for membrane remodeling and pathogen trafficking.

Control of protein activity by photoinduced spin polarized charge reorganization

This study demonstrates that photoinduced spin polarized charge reorganization within proteins can modulate enzyme activity and protein-protein interactions.

Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

This study shows that tonic interferon signaling maintains immune homeostasis by regulating gut microbiota, preventing IL-17-driven inflammation and myeloid hyperplasia in STAT1 KO mice.

On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing

This study investigates amino acid luminescence in aggregated states, finding that supramolecular packing, not chemical properties, drives visible light emission and reversible optical transitions.

Substrates modulate charge-reorganization allosteric effects in protein-protein association

The paper investigates how charged substrates modulate charge-reorganization allosteric effects in protein-protein association, showing that ATP reduces this effect by over 50%.

Nanoscale architecture of a VAP-A-OSBP tethering complex at membrane contact site

The paper investigates the nanoscale structure of a VAP-A-OSBP tethering complex at membrane contact sites using in vitro models and cryo-tomography.

Single chromosome gains can function as metastasis suppressors and metastasis promoters

The paper investigates how single chromosome gains can either suppress or promote metastasis in cancer, showing that specific aneuploidies are linked to distinct clinical outcomes.

Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein

This study shows that ultra-short laser-accelerated proton pulses can increase cancer cell mortality in radioresistant cells when PARP1 function is intact.