Author

B. V. Adkar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 4 Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

S. Bhattacharyya· 5 shared E. I. Shakhnovich· 4 shared E. Shakhnovich· 2 shared M. Manhart· 2 shared W. Zhang· 2 shared A. I. Gilson· 1 shared D. Levy· 1 shared D. Scheerer· 1 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersBiophysics

S. Bhattacharyya

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Author profile →

6 papers

Recent·Most cited

Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase

D. Scheerer, B. V. Adkar, S. Bhattacharyya, D. Levy, M. Iljina, I. Riven, O. Dym, G. Haran, E. Shakhnovich

This study investigates how AMP substrate inhibition in adenylate kinase is modulated by domain motions, showing that inhibitory concentrations of AMP increase domain closure and affect catalytic activity.

bioRxiv · Nov 21, 2022 · PreprintBiophysics

Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype

S. Bhattacharyya, S. Bershtein, B. V. Adkar, J. Woodard, E. Shakhnovich

The paper investigates how point mutations in DHFR affect E. coli metabolism and phenotype by analyzing dTTP levels and enzyme kinetics.

bioRxiv · Dec 16, 2020Biophysics

Substrate inhibition imposes fitness penalty at high protein stability

B. V. Adkar, S. Bhattacharyya, A. I. Gilson, W. Zhang, E. I. Shakhnovich

The paper shows that mutations increasing protein stability in E. coli adenylate kinase lead to substrate inhibition by AMP, reducing enzyme activity and fitness.

bioRxiv · Dec 19, 2018Biophysics

Accessibility of the Shine-Dalgarno sequence dictates N-terminal codon bias in E. coli

S. Bhattacharyya, W. M. Jacobs, B. V. Adkar, J. Yan, W. Zhang, E. I. Shakhnovich

The paper shows that Shine-Dalgarno sequence accessibility affects N-terminal codon bias in E. coli by modulating translation initiation efficiency.

bioRxiv · Mar 2, 2018Biophysics

Tradeoffs between microbial growth phases lead to frequency-dependent and non-transitive selection

M. Manhart, B. V. Adkar, E. I. Shakhnovich

The paper models microbial growth phases to show how tradeoffs between growth, lag time, and yield lead to frequency-dependent and non-transitive selection.

Proceedings of the Royal Society B: Biological Sciences · Feb 14, 2018Peer-reviewedEvolutionary Biology

Optimization of lag phase shapes the evolution of a bacterial enzyme

B. V. Adkar, M. Manhart, S. Bhattacharyya, J. Tian, M. Musharbash, E. I. Shakhnovich

This study examines how mutations in E. coli's Adenylate Kinase affect growth phases, revealing that catalytic capacity optimizes lag time while growth rates are less affected.

Nature Ecology & Evolution · Apr 28, 2017Peer-reviewedEvolutionary Biology