M. Weller

Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling

The paper analyzes multi-omics data from IDH-mutant astrocytomas to identify molecular markers of malignant progression linked to cell cycling and DNA methylation changes.

Epigenetic modification and characterization of the MGMT promoter region using CRISPRoff in glioblastoma cells

This study uses CRISPRoff to introduce site-specific CpG methylation in the MGMT promoter of glioblastoma cells, showing reduced MGMT expression and increased temozolomide sensitivity.

Integrative spatial analysis reveals a multi-layered organization of glioblastoma

This study uses spatial transcriptomics and proteomics to reveal three modes of cellular organization in glioblastoma, with hypoxia driving a 5-layered global architecture.

BCAT1 inhibition affects CD8+ T cell activation, exhaustion, and tumoral immunity by altering iron homeostasis

This study shows BCAT1 inhibition alters iron homeostasis, affecting CD8+ T cell activation, exhaustion, and tumor immunity, with potential as a cancer therapy.

The Siglec-sialic acid-axis is a target for innate immunotherapy of glioblastoma

This study identifies the Siglec-sialic acid-axis as a target for innate immunotherapy in glioblastoma, showing that blocking Siglec-E enhances phagocytosis and T cell priming, leading to delayed tumor growth and prolonged survival.

Targeting tumour-intrinsic neural vulnerabilities of glioblastoma

This study identifies neural vulnerabilities in glioblastoma by analyzing patient samples and model systems, revealing drug targets and pathways that can be exploited for treatment.

Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment

This study analyzes longitudinal glioma data to identify recurrence-associated changes in genetics and microenvironment linked to therapy resistance.

DNA methylation and survival differences associated with the type of IDH mutation in 1p/19q non-codeleted astrocytomas

The paper shows that IDH mutations other than p.R132H in 1p/19q non-codeleted astrocytomas are linked to higher DNA methylation and better patient survival.

Overall patient's survival of glioblastoma associated to molecular markers: a pan-proteomic prospective study

This paper identifies three molecular groups of glioblastoma (GBM) associated with different survival outcomes using pan-proteomic analysis and validates prognostic markers for improved patient stratification.

A drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent local relapse and treat established brain metastasis

The paper introduces a drug-screening platform using organotypic cultures to identify effective treatments for brain metastasis, finding a potent HSP90 inhibitor that works against mouse and human metastases.

High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

Linking Dendroecology And Association Genetics: Stress Responses Archived In Tree Rings Associate With SNP Genotypes In Abies alba (Mill.)

This study links dendroecological data with genetic association analysis in silver fir, identifying 15 candidate genes related to stress response traits archived in tree rings.