Author

D. Speck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

P. Scheerer· 2 shared A. Beck-Sickinger· 1 shared A. Koch· 1 shared A. Schmidt· 1 shared B. Bauer· 1 shared B. Bruegger· 1 shared B. K. Kobilka· 1 shared B. Kuropka· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

P. Scheerer

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2 papers

Recent·Most cited

T cell interaction partners of DHHC20

D. Haxhiraj, B. Kuropka, E. Brencher, D. Rosenberger, H. Brandt, D. Speck, P. Scheerer, B. Bruegger, C. Clementi, C. Freund

This study identifies DHHC20 interaction partners in T cells, showing it interacts with Gsβ1γ2 and suggests a model for its role in palmitoylation.

bioRxiv · Feb 14, 2024 · PreprintBiochemistry

Structures of active melanocortin-4 receptor--Gs-protein complexes with NDP-α-MSH and setmelanotide

N. A. Heyder, G. Kleinau, D. Speck, A. Schmidt, S. Paisdzior, M. Szczepek, B. Bauer, A. Koch, M. Gallandi, D. Kwiatkowski, J. Bürger, T. Mielke, A. Beck-Sickinger, P. W. Hildebrand, C. M. T. Spahn, , P. Scheerer

The paper presents cryo-EM structures of MC4R-Gs complexes with NDP-α-MSH and setmelanotide, revealing ligand-specific interactions and activation mechanisms.

bioRxiv · Apr 22, 2021Biochemistry