A. Schmidt

The major nucleoid-associated protein WHIRLY1 promotes chloroplast development in barley

This study characterizes the barley WHIRLY1 mutant, showing it promotes chloroplast development by remodeling nucleoids and coordinating protein expression, but is not essential for chloroplast biogenesis.

Bacterial RNA promotes proteostasis through inter-tissuecommunication in C. elegans

The paper shows that bacterial-derived RNA extends healthspan in C. elegans by reducing protein aggregation through inter-tissue communication and systemic RNAi.

Decoding the Baltic Sea's Past and Present: A simple Molecular Index for Ecosystem Assessment

This paper develops a DNA-based index using ancient sediment DNA to assess past and present phytoplankton dominance in the Baltic Sea, revealing historical shifts in species composition.

The crystal structure of the Shethna Protein II (FeSII) from Azotobacter vinelandii suggests a domain swap

The paper reinterprets the crystal structure of FeSII from Azotobacter vinelandii, proposing a domain swap rather than an open conformation due to oxidation state.

Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunisation in the pig lung

This study uses single-cell RNA sequencing and flow cytometry to analyze immunological changes in pig lungs after influenza infection or vaccination, revealing lasting effects on immune cell populations and function.

SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation

This study shows SGLT2 inhibitors reduce endothelial to mesenchymal transition and cardiac fibroblast activation through effects on mitochondrial respiration, actin cytoskeleton, and specific transporters.

ALK signalling primes the DNA damage response sensitizing ALK-driven neuroblastoma to ATR inhibition

This study identifies ALK signaling's role in enhancing DNA damage response in neuroblastoma, showing that combined ATR/ALK inhibition leads to sustained tumor response and differentiation.

Heterologous sarbecovirus receptor binding domains as scaffolds for SARS-CoV-2 receptor binding motif presentation

This study designs immunogens by grafting SARS-2 RBM onto heterologous sarbecovirus scaffolds to elicit broad neutralizing antibodies against sarbecoviruses.

The first European woolly rhinoceros mitogenomes retrieved from within cave hyena coprolites suggest long-lasting phylogeographic differentiation

The paper retrieves the first European woolly rhinoceros mitogenomes from cave hyena coprolites, showing genetic distinction from Siberian populations and suggesting a population split.

Helicobacter pylori attachment-blocking antibodies protect against duodenal ulcer disease

The paper shows that antibodies blocking H. pylori attachment reduce chronic inflammation and duodenal ulcer risk by mimicking BabA's binding to ABO glycans.

Genetic analysis of rab7 mutants in zebrafish

This study investigates the role of Rab7 genes in zebrafish vascular development, showing their involvement in lumen formation and identifying functional redundancy and maternal contributions.

Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins

The paper investigates the role of Drosophila Polychaetoid/ZO-1 in strengthening cell junctions under tension and its distinct localization compared to core adherens junction proteins.

Plastid fatty acid export (FAX) proteins in Arabidopsis thaliana - the role of FAX1 and FAX3 in growth and development

This study defines the structural features of plant FAX proteins in plastids and shows that FAX1 and FAX3 have complementary functions in vegetative leaf growth.

Mechanisms that promote the evolution of cross-reactive antibodies upon vaccination with designed influenza immunogens

The paper develops a computational model to study antibody evolution after vaccination with designed influenza immunogens, finding that a chimeric antigen outperforms a cocktail in eliciting RBS-directed antibodies due to T cell interactions.

Differential expression analysis of sexual and apomictic Boechera uncovers FAS4 as crucial for gametogenesis

This study identifies FAS4 as crucial for gametogenesis by comparing sexual and apomictic Boechera reproductive tissues through RNA-Seq.

Quantitative proteomic analysis of skeletal muscles from wild type and transgenic mice carrying recessive Ryr1 mutations linked to congenital myopathies

The paper quantitatively analyzes proteomic differences in skeletal muscles of wild type and Ryr1 mutant mice, revealing reduced RyR1 and altered protein content linked to congenital myopathies.

Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds

This study shows DNA origami scaffolds enhance antibody responses to SARS-CoV-2 RBD without inducing immune memory against the scaffold itself, compared to protein-based VLPs.

Preclinical establishment of a divalent vaccine against SARS-CoV-2

This paper develops a divalent vaccine against SARS-CoV-2 that induces strong IgG responses and T-cell activation, showing durability and cross-variant protection.

Elevation drives activity of soil bacteria, but not of bacterial viruses

The paper investigates how elevation affects bacterial and bacteriophage activity in soil using metatranscriptomics across an elevational gradient in the Swiss Alps.

Disassembly of hemidesmosomes promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin into focal adhesions

This study shows that loss of PTEN and hemidesmosomes in prostate cancer promotes tumorigenesis by activating EGFR/PI3K/Akt and FAK/Src pathways through plectin mislocalization.

Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter

This study investigates the mechanism of LtaA, a proton-dependent MFS lipid transporter, revealing a trap-and-flip mechanism for lipid translocation.

Protective mucosal immunity against SARS-CoV-2 after heterologous systemic RNA-mucosal adenoviral vector immunization

This study shows that intranasal adenoviral vector boosts after mRNA priming enhance mucosal immunity and protection against SARS-CoV-2 in mice.

Cryo-EM structure of native human thyroglobulin

The paper presents the cryo-EM structure of human thyroglobulin, revealing its 3D structure and providing insights into hormone synthesis and glycosylation sites.

Computer-Assisted Mitotic Count Using a Deep Learning-based Algorithm Improves Inter-Observer Reproducibility and Accuracy in canine cutaneous mast cell tumors

Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19

The paper profiles early humoral immune responses in COVID-19 patients, finding that survivors show rapid SARS-CoV-2-specific immunity linked to pre-existing OC43 immunity, while non-survivors have delayed and blunted responses.

Structures of active melanocortin-4 receptor--Gs-protein complexes with NDP-α-MSH and setmelanotide

The paper presents cryo-EM structures of MC4R-Gs complexes with NDP-α-MSH and setmelanotide, revealing ligand-specific interactions and activation mechanisms.

Proteogenomic characterization of hepatocellular carcinoma

This study identifies differentially regulated pathways and candidate driver genes in hepatocellular carcinomas through proteogenomic analysis across clinical stages and etiologies.

Specific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata

The paper identifies UGT enzymes involved in the biosynthesis of HGL-DTGs in Nicotiana attenuata and shows that glucosylation prevents autotoxicity while enhancing defense against herbivores.

Bacterial protein domains with a novel Ig-like fold bind human CEACAM receptors

This study identifies a novel Ig-like fold in bacterial adhesins that binds human CEACAM receptors, suggesting a broad mechanism for bacterial pathogenesis.

Single-cell analysis of intestinal immune cells during helminth infection

The paper optimizes a protocol to isolate immune cells from helminth-infected intestines and analyzes their characteristics during infection.