Author

G. Kleinau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

P. Scheerer· 4 shared H. Biebermann· 2 shared M. J. Lohse· 2 shared A. Beck-Sickinger· 1 shared A. Brenlla-Lopez· 1 shared A. G. Beck-Sickinger· 1 shared A. Koch· 1 shared A. Morton· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersPharmacology & Toxicology

P. Scheerer

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MRAP2 modifies signaling and oligomerization state of the melanocortin-4 receptor

I. Sohail, S.-A. Laurin, G. Kleinau, V. Chunilal, A. Morton, A. Brenlla-Lopez, Z. C. U. Kagiali, J. A. Tello, M.-J. Blouin, A. G. Beck-Sickinger, M. J. Lohse, P. Scheerer, M. Bouvier, P. McCormick, P. Annibale, H. Biebermann

This study shows that MRAP2 modifies MC4R signaling and oligomerization, enhancing G protein signaling while reducing beta-arrestin2 recruitment and receptor internalization.

bioRxiv · Apr 9, 2024Pharmacology & Toxicology

Is the neuropeptide PEN a ligand of GPR83?

Y. Giesecke, V. Asimi, V. Stulberg, G. Kleinau, P. Scheerer, B. Koksch, C. Groetzinger

This study investigates whether PEN is a ligand of GPR83 and finds no evidence supporting this claim through multiple assays.

bioRxiv · Aug 31, 2023 · PreprintPharmacology & Toxicology

Functional modulation of PTH1R activation and signalling by RAMP2

K. Nemec, H. Schihada, G. Kleinau, U. Zabel, E. O. Grushevskyi, P. Scheerer, M. J. Lohse, I. Maiellaro

This study shows RAMP2 modulates PTH1R activation and signalling, enhancing Gi3 sensitivity and β-arrestin2 recruitment in a ligand-dependent manner.

bioRxiv · Dec 8, 2021 · PreprintPharmacology & Toxicology

Structures of active melanocortin-4 receptor--Gs-protein complexes with NDP-α-MSH and setmelanotide

N. A. Heyder, G. Kleinau, D. Speck, A. Schmidt, S. Paisdzior, M. Szczepek, B. Bauer, A. Koch, M. Gallandi, D. Kwiatkowski, J. Bürger, T. Mielke, A. Beck-Sickinger, P. W. Hildebrand, C. M. T. Spahn, , P. Scheerer

The paper presents cryo-EM structures of MC4R-Gs complexes with NDP-α-MSH and setmelanotide, revealing ligand-specific interactions and activation mechanisms.

bioRxiv · Apr 22, 2021Biochemistry