BiochemistrybioRxiv
Structures of active melanocortin-4 receptor--Gs-protein complexes with NDP-α-MSH and setmelanotide
N. A. Heyder, G. Kleinau, D. Speck…·P. Scheerer
The paper presents cryo-EM structures of MC4R-Gs complexes with NDP-α-MSH and setmelanotide, revealing ligand-specific interactions and activation mechanisms.