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D. T. F. Dryden

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Biophysics· 1

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Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Assay:structural biology· 1

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F. Ye· 1 shared I. Kotta-Loizou· 1 shared M. Buck· 1 shared M. Jovanovic· 1 shared X. Liu· 1 shared X. ZhangiD· 1 shared

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1 shared paperBiophysics

F. Ye

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BiophysicseLifePeer-reviewedFeb 10, 2020

Structural basis of transcription inhibition by the DNA mimic protein Ocr of bacteriophage T7

X. Zhang, F. Ye, I. Kotta-Loizou…·M. Buck

This study reveals that the Ocr protein from bacteriophage T7 inhibits host transcription by binding to RNA polymerase and competing with sigma factors, providing a structural basis for its dual role in evading host defenses.

DOI 10.7554/elife.52125

E. colistructural biology

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