Author

D. W. Abbott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. P. Tingley· 3 shared J. E. Hill· 2 shared P. Bhandari· 2 shared A. Aderem· 1 shared A. D. Smith· 1 shared A. Enders· 1 shared A. M. Buckle· 1 shared A. Russell· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

J. P. Tingley

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Author profile →

4 papers

Recent·Most cited

Glycogen degrading activities of catalytic domains of α-amylase and α-amylase-pullulanase enzymes conserved in Gardnerella spp. from the vaginal microbiome

P. Bhandari, J. P. Tingley, D. W. Abbott, J. E. Hill

This study identifies and characterizes glycogen-degrading enzymes in Gardnerella spp. that break down glycogen into maltose, maltotriose, and maltotetraose, contributing to nutrient competition in the vaginal microbiome.

bioRxiv · Oct 19, 2022Microbiology

Characterization of an α-glucosidase enzyme conserved in Gardnerella spp. isolated from the human vaginal microbiome

P. Bhandari, J. P. Tingley, D. R. Palmer, D. W. Abbott, J. E. Hill

This study identifies and characterizes a conserved α-glucosidase in Gardnerella spp. that hydrolyzes maltooligosaccharides but not glycogen, suggesting a role in glycogen metabolism in the vaginal microbiome.

Journal of Bacteriology · Aug 9, 2021Peer-reviewedMicrobiology

Quantifying fluorescent glycan uptake to elucidate strain-level variability in foraging behaviors of rumen bacteria

L. Klassen, G. Reintjes, J. P. Tingley, D. R. Jones, J.-H. Hehemann, A. D. Smith, T. D. Schwinghamer, C. Arnosti, L. Jin, T. W. Alexander, C. Amundsen, D. Thomas, R. Amann, T. A. McAllister, D. W. Abbott

The paper uses fluorescent glycan uptake and genomic analyses to study strain-level differences in carbohydrate metabolism among rumen bacteria.

bioRxiv · Jun 8, 2020Microbiology

Phospho-tuning immunity through Denisovan, modern human, and mouse TNFAIP3 gene variants

N. W. Zammit, O. M. Siggs, P. Gray, K. Horikawa, S. R. Daley, D. B. Langley, D. Cultrone, E. K. Malle, S. N. Walters, J. E. Villanueva, J. Warren, A. Russell, M. J. Cowley, V. Gayevskiy, M. E. Dinger, , M. E. Craig

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

bioRxiv · Mar 27, 2019 · PreprintImmunology