Author

A. Aderem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 6 Organism:mouse· 6 Research Focus:host-pathogen & immune response· 5 Assay:bulk RNA-seq· 4 Approach:statistical model· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3

Frequent Co-Authors

D. Mai· 4 shared A. C. Rothchild· 3 shared A. H. Diercks· 3 shared J. S. Johnson· 3 shared A. Jahn· 2 shared A. Kaushansky· 2 shared A. N. Douglass· 2 shared A. Rothchild· 2 shared

Activity by Year

2018-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersImmunology

D. Mai

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

CD4-mediated immunity shapes neutrophil-driven tuberculous pathology

B. H. Gern, J. M. Klas, K. A. Foster, S. B. Cohen, C. R. Plumlee, F. J. Duffy, M. L. Neal, M. Halima, A. T. Gustin, A. H. Diercks, A. Aderem, M. Gale, J. D. Aitchison, M. Y. Gerner, K. B. Urdahl

This study shows that prior immunity influences tuberculosis lesion structure by modulating neutrophil and T cell responses, leading to different pathological outcomes.

bioRxiv · Apr 12, 2024Immunology

Exposure to mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection

D. Mai, A. Jahn, T. Murray, M. Morikubo, P. N. Lim, M. M. Cervantes, L. K. Pham, J. C. Nemeth, K. B. Urdahl, A. H. Diercks, A. Aderem, A. C. Rothchild

This study shows that prior exposure to mycobacteria remodels alveolar macrophages, enhancing their pro-inflammatory response to Mtb infection through both intrinsic changes and environmental factors.

bioRxiv · Sep 19, 2022Immunology

A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection.

K. Vijayan, N. Arang, L. Wei, R. Morrison, R. Geiger, R. K. Parks, A. J. Lewis, F. D. Mast, A. N. Douglass, H. S. Kain, J. D. Aitchison, J. S. Johnson, A. Aderem, A. Kaushansky

bioRxiv · Aug 31, 2020Cell Biology

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

Y. Su, D. Chen, C. Lausted, D. Yuan, J. Choi, C. Dai, V. Voillet, K. Scherler, P. Troisch, V. R. Duvvuri, P. Baloni, G. Qin, B. Smith, S. Kornilov, C. Rostomily, , the

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

bioRxiv · Jul 27, 2020 · PreprintImmunology

Phospho-tuning immunity through Denisovan, modern human, and mouse TNFAIP3 gene variants

N. W. Zammit, O. M. Siggs, P. Gray, K. Horikawa, S. R. Daley, D. B. Langley, D. Cultrone, E. K. Malle, S. N. Walters, J. E. Villanueva, J. Warren, A. Russell, M. J. Cowley, V. Gayevskiy, M. E. Dinger, , M. E. Craig

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

bioRxiv · Mar 27, 2019 · PreprintImmunology

Alveolar macrophages up-regulate a non-classical innate response to Mycobacterium tuberculosis infection in vivo

A. C. Rothchild, G. S. Olson, J. Nemeth, L. M. Amon, D. Mai, E. S. Gold, A. H. Diercks, A. Aderem

Alveolar macrophages infected with Mtb in vivo up-regulate an Nrf2-dependent antioxidant response instead of a pro-inflammatory response, impairing bacterial control.

bioRxiv · Mar 18, 2019 · PreprintImmunology

A comprehensive map of the dendritic cell transcriptional network engaged upon innate sensing of HIV

J. S. Johnson, N. De Veaux, A. W. Rives, X. Lahaye, S. Y. Lucas, B. Perot, M. Luka, L. M. Amon, A. Watters, A. Aderem, N. Manel, D. R. Littman, R. Bonneau, M. M. Menager

This study maps the transcriptional network in HIV-1 infected dendritic cells, identifying key regulators of interferon response and maturation.

bioRxiv · Mar 18, 2019Immunology

An essential mycolate remodeling program for mycobacterial adaptation in host cells

E. J. R. Peterson, R. Bailo, A. C. Rothchild, M. Arrieta-Ortiz, A. Kaur, M. Pan, D. Mai, C. Cooper, A. Aderem, A. Bhatt, N. Baliga

The paper introduces Path-seq to study MTB transcription in host cells and identifies a mycolate remodeling program regulated by MadR during infection.

Molecular Systems Biology · Mar 4, 2019Peer-reviewedMicrobiology

Latent Mycobacterium tuberculosis infection provides protection for the host by changing the activation state of the innate immune system

J. Nemeth, G. S. Olson, A. Rothchild, A. Jahn, D. Mai, F. Duffy, J. Delahaye, S. Srivatsan, C. Plumlee, K. Urdahl, E. Gold, A. Diercks, A. Aderem

This study shows that latent Mycobacterium tuberculosis infection protects hosts by altering the activation state of the innate immune system in both mice and humans.

bioRxiv · Feb 27, 2019Immunology

Ferroptosis-like signaling facilitates a potent innate defense against Plasmodium infection

H. S. Kain, N. Arang, E. Glennon, A. N. Douglass, D. R. Dudgeon, J. S. Johnson, A. Aderem, A. Kaushansky

This study shows that ferroptosis-like signaling controls Plasmodium liver infection by reducing parasite survival and enhancing host cell death.

bioRxiv · Jan 31, 2018Microbiology