A. Russell

Can biocrust moss hide from climate change? Fine-scale habitat sheltering improves summer-stress resistance in Syntrichia caninervis

This study shows that fine-scale habitat features, like slope and shrub shading, better protect mosses from summer stress than elevation-based climate differences.

Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis

This study uses multi-omics analysis to show coordinated changes in epithelial, stromal, and immune compartments during Barrett's Esophagus progression to adenocarcinoma, revealing early appearance of cancer-associated fibroblasts and immunosuppressive microenvironment.

Efficient genetic editing of human intestinal organoids using ribonucleoprotein-based CRISPR

This study develops an efficient ribonucleoprotein-based CRISPR method for editing human intestinal organoids, achieving 98% editing efficiency with no off-target effects and revealing PTEN loss phenotypes.

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

The paper identifies 14q32 cluster miRNAs as key regulators of transcriptional differences between IGHV-mutated and unmutated CLL, with miR-409-3p and miR-411-3p repressing GAB1.

Environmental and genetic disease modifiers of haploinsufficiency of A20

The paper identifies genetic and environmental modifiers that exacerbate autoinflammatory disease caused by A20 haploinsufficiency in humans.

Cross-talk between cAMP and Ca2+ signalling in cardiac pacemaker cells involves IP3-evoked Ca2+ release and stimulation of adenylyl cyclase 1

This study investigates the role of AC1 in atrial pacemaker activity response to β-adrenergic stimulation and IP3R calcium release in mouse and guinea pig atrial tissues.

Computational design of highly signaling active membrane receptors through de novo solvent-mediated allosteric networks

This paper designs novel membrane receptors with enhanced activity and stability through engineered allosteric networks involving solvent-mediated interactions.

Evolutionary transition to XY sex chromosomes associated with Y-linked duplication of a male hormone gene in a terrestrial isopod

The paper investigates sex chromosome evolution in Trachelipus rathkei, finding an XX/XY system with Y-linked duplication of a male hormone gene and evidence of Wolbachia influence.

A novel tubulin binding molecule drives differentiation of acute myeloid leukaemia cells

The paper identifies a novel tubulin-binding molecule that induces differentiation in AML cells, reducing tumour burden and improving survival in vivo.

Transmission of vibrations in buzz-pollinated plant species with disparate floral morphologies

The paper compares vibration transmission in buzz-pollinated flowers with different anther arrangements, finding that tight anther packing leads to uniform vibration transmission, while loose arrangements result in higher displacement in non-focal anthers.

A phenotypic screen identifies a compound series that induces differentiation of acute myeloid leukemia cells in vitro and shows anti-tumour effects in vivo

Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GAP Rga4

The paper shows that Cdc42 reactivation at growth sites in fission yeast is controlled by the cell-cycle-dependent loss of its GAP Rga4.

Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice

This study shows that loss-of-function mutations in Fbxo10 do not increase BCL2 or B lymphocyte numbers in mice, suggesting redundant regulation of BCL2 by other ubiquitin ligases.

Pex11 β knockdown decreases peroxisome abundance and reverses the inhibitory effect of palmitate on pancreatic beta-cell function.

This study shows that reducing Pex11β decreases peroxisomes and reverses palmitate's negative impact on beta-cell function.

The use of CRISPR for variant specificity in the genetic diagnosis of primary immunodeficiency disease (PID)

The paper uses CRISPR to validate a specific IL-6R variant in primary human T lymphocytes as causative for PID, demonstrating its utility for assessing genetic defects in T lymphocytes.

A rapid and automated sample-to-result Candida auris real-time PCR assay for high throughput testing of surveillance samples with BD MAX™ open system

This paper develops an automated real-time PCR assay for rapid detection of Candida auris using the BD MAX system, achieving high sensitivity and specificity in clinical samples.

Phospho-tuning immunity through Denisovan, modern human, and mouse TNFAIP3 gene variants

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.