David A. Bennett

Differential Associations of Microglial Inflammation on LATE-NC and Tangle-Related Hippocampal Atrophy

This study investigates how microglial inflammation affects hippocampal volume in relation to AD and LATE-NC, finding that microglia enhance LATE-NC's impact on volume loss but not AD.

CD33 and Clusterin Interact Biophysically and Genetically to Modulate Alzheimer Risk

This study shows how non-coding variants in CD33 affect Alzheimer's risk by altering CD33M dimerization and interactions with clusterin and Aβ, impacting microglial function.

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.

This study identifies genetic loci and pathways associated with limbic white matter microstructure in aging and Alzheimer's Disease using multi-cohort diffusion MRI and bulk RNA-seq data.

Post-translational modifications in the brain are critical contributors to Alzheimers disease neuropathology and cognitive decline

This study identifies novel post-translational modifications in Alzheimer's disease brains linked to neuropathology and cognition using mass spectrometry data from 101 participants.

Blood-based Transcriptomics Reveal Sex- and Amyloid-Modulated Biology of Plasma pTau217 in Preclinical Alzheimer's Disease

The paper identifies gene associations with plasma pTau217 in preclinical Alzheimer's disease, showing modulation by APOEε4, Aβ-PET, and sex, with X-linked genes playing a role.

INPP5D/SHIP1 regulates endo-lysosome function and cargo-selective phagocytosis in human microglia

This study shows that INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia, linking its dysfunction to Alzheimer's disease pathology.

Sex-specific Associations of Gene Expression with Alzheimer's Disease Neuropathology and Ante-mortem Cognitive Performance

The paper examines sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive performance using bulk transcriptomic data from 767 individuals.

Cytokine expression profile in the human brain of older adults

This study examines cytokine gene expression in human brain tissue from elderly individuals with and without Alzheimer's disease to identify biomarkers and understand disease mechanisms.

A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations

This paper develops an APOE-independent polygenic risk score for Alzheimer's disease that shows associations with cognitive decline and neuropathological markers across diverse populations.

Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures

This paper identifies genome-wide pleiotropic loci linking blood pressure and cognitive performance measures using longitudinal data from multiple cohorts.

Modeling Stimulus-Induced Stress Responses in Microglia-like Cells Using a Commercial iPSC-dCas9-KRAB Line

The paper evaluates the AICS-0090 dCas9-KRAB iPSC line for modeling microglia-like cells and their responses to disease-relevant stimuli, finding stimulus-specific transcriptomic and functional responses.

Genotyping TOMM40'523 Poly-T Polymorphisms Using Whole-Genome Sequencing

This paper introduces a computational pipeline for genotyping TOMM40 poly-T polymorphisms from whole-genome sequencing data, achieving high accuracy and consistency with PCR-based genotypes.

Uncovering Plaque-Glia Niches in Human Alzheimer's Disease Brains Using Spatial Transcriptomics

The paper uses spatial transcriptomics to analyze Aβ plaques and glial interactions in AD brains, finding that low Aβ areas show more neuronal loss and high-glia areas show inflammation and neurodegeneration.

Genetic insights into the association between inflammatory bowel disease and Alzheimer's disease

This study investigates the genetic overlap between inflammatory bowel disease and Alzheimer's disease, finding distinct myeloid cell-specific risk factors and some protective associations.

Proteome-wide association studies using summary pQTL data of three tissues identified 30 risk genes of Alzheimer's disease dementia

Early neuronal reprogramming and cell cycle reentry shape Alzheimer's disease progression

The paper identifies early transcriptional changes in neuronal subtypes in Alzheimer's disease using single-nucleus RNA data, revealing distinct programs linked to vulnerability and resilience.

Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults

The paper identifies sex-specific genetic loci associated with memory, executive functioning, and language performance in older adults through genome-wide meta-analyses.

TDP-43 toxic gain of function links ALS, FTD and Alzheimers Disease through splicing dysregulation

This study identifies TDP-43-driven splicing dysregulation as a common mechanism in ALS, FTD, and Alzheimer's disease, linking them through mis-spliced mRNAs like APP.

Cell type transcriptomics reveal shared genetic mechanisms in Alzheimer's and Parkinson's disease

The paper identifies shared molecular mechanisms between Alzheimer's and Parkinson's disease by analyzing gene co-expression at sub-cell-type resolution using single-nucleus datasets.

Contributions of genetic variation in astrocytes to cell and molecular mechanisms of risk and resilience to late onset Alzheimer's disease

The paper uses iPSC-derived astrocytes to study genetic risk factors for Alzheimer's disease, finding concordant molecular changes in both astrocytes and brain tissue.

Multi-Omics Analysis for Identifying Cell-Type-Specific Druggable Targets in Alzheimer's Disease

This study identifies cell-type-specific druggable targets in Alzheimer's disease by integrating GWAS and eQTL data across multiple cell types and datasets.

Large- Scale Deep Proteomic Analysis in Alzheimer's Disease Brain Regions Across Race and Ethnicity

The paper performs large-scale proteomic analysis of Alzheimer's disease brain regions across different racial and ethnic groups, identifying AD-related protein changes and APOE4 concordance with genotype.

Integrated Spatial and Single-Nuclei Transcriptomic Analysis of Long Non-Coding RNAs in Alzheimer's Disease

The paper identifies AD-associated lncRNAs with spatial and cell-type-specific expression patterns and shows OIP5-AS1 contributes to microglial activation in AD.

The YTHDF proteins shape the brain gene signatures of Alzheimer's disease

This study identifies YTHDF proteins as key regulators of Alzheimer's disease brain gene signatures through m6A-dependent and independent mechanisms.

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts

The paper quantifies somatic mitochondrial DNA insertions (Numts) in human brain and fibroblasts, showing their accumulation over time and association with lifespan.

Testing a polygenic risk score for morphological microglial activation in Alzheimer's disease and aging

The paper tests a polygenic risk score for microglial activation in Alzheimer's disease and aging, finding no significant improvement in predictive power for AD diagnosis or cognitive performance.

Perturbed functional networks in Alzheimers Disease reveal opposing roles for TGIF and EGR3

The paper identifies TGIF1 and EGR3 as master regulators in Alzheimer's Disease by integrating gene expression and protein interactions, revealing their opposing roles in neuroprotection and synaptic deficits.