Dorota Klepacki

This study shows that structural modifications of oxazolidinone antibiotics alter their preference for specific penultimate amino acids during translation inhibition.

This study identifies bottromycin's mechanism of action as selectively trapping EF-Tu/glycyl-tRNA complex on the ribosome, inhibiting translation at glycine codons.

This study identifies Drosocin as a type II PrAMP that inhibits protein synthesis termination by stalling ribosomes at stop codons, distinct from apidaecin.

The paper presents high-resolution structures of ribosomal complexes with chloramphenicol and specific nascent peptides, revealing how amino acids in the nascent chain modulate drug affinity and explain context-specific inhibition of translation.

The paper investigates how the TnaC-ribosome complex recognizes and responds to L-Trp, revealing a mechanism involving cleavage rates and ligand binding.

The paper uses retapamulin-assisted ribosome profiling to identify alternative translation start sites in E. coli, revealing new proteins and regulatory roles.