James Marks

Fatty Acid Synthase Binds Cellular mRNAs and its Depletion Reduces Translational Efficiency

This study identifies FASN's RNA binding sites and shows its depletion reduces translational efficiency of associated mRNAs.

Quantitative profiling of basal and stress-induced ribosome collisions

The paper quantifies disome levels across the transcriptome in yeast and human cells under basal and stress conditions, showing stress-induced increases and context-dependent redistribution.

5-Azacytidine incorporation into mRNAs disrupts translation and induces ribosome collisions

This study shows 5-AzaC incorporation into mRNAs disrupts translation, causes ribosome collisions, and activates stress responses, contributing to its cytotoxicity beyond DNA hypomethylation.

Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria

This study investigates how antibiotics inhibit mitochondrial translation, finding that most act similarly to their bacterial targets and identifying errors in annotated mitochondrial translation initiation sites.

Retapamulin-assisted ribosome profiling reveals the alternative bacterial proteome

The paper uses retapamulin-assisted ribosome profiling to identify alternative translation start sites in E. coli, revealing new proteins and regulatory roles.