Pax Protein Depletion in Proximal Tubules Triggers Conserved Mechanisms of Resistance to Acute Ischemic Kidney Injury and Prevents Transition to Chronic Kidney Disease
J. A. Beamish, A. C. Telang, M. C. McElliott, A. Al-Suraimi, M. Chowdhury, J. T. Ference-Salo, E. A. Otto, R. Menon, A. Soofi, J. M. Weinberg, S. R. Patel, G. R. Dressler
This study shows that deleting Pax2 and Pax8 in proximal tubules reduces acute kidney injury severity and prevents chronic disease by inducing protective gene expression similar to preconditioning.
bioRxiv · Oct 3, 2023 · PreprintPathology