R. Menon

A Novel Tiled-Amplicon Sequencing Assay Targeting the Tomato Brown Rugose Fruit Virus (ToBRFV) Genome Reveals Widespread Distribution in Municipal Wastewater Treatment Systems in the Province of Ontario, Canada

The paper develops a tiled-amplicon sequencing assay to detect and track ToBRFV in municipal wastewater, revealing its widespread distribution in Ontario, Canada.

Pax Protein Depletion in Proximal Tubules Triggers Conserved Mechanisms of Resistance to Acute Ischemic Kidney Injury and Prevents Transition to Chronic Kidney Disease

This study shows that deleting Pax2 and Pax8 in proximal tubules reduces acute kidney injury severity and prevents chronic disease by inducing protective gene expression similar to preconditioning.

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritis

This study identifies conserved myeloid subsets and disease-associated gene expression changes in kidney injury across lupus mouse models and human patients with lupus nephritis.

Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

This study shows that oral administration of indole-3-acetate reduces liver steatosis and inflammation in mice fed a high-fat diet.

Simultaneous Spectral Differentiation of Multiple Fluorophores in Super-resolution Imaging Using a Glass Phase Plate

This paper introduces a method to simultaneously image and distinguish multiple fluorophores in super-resolution microscopy using a phase plate and computational algorithm.

Injectable Progranulin-derivative Atsttrin loaded Protein Engineered Gels for Post Traumatic Osteoarthritis

This paper develops a protein-based gel that delivers Atsttrin to prevent post-traumatic osteoarthritis in a rabbit model.

Repurposing statin and L-glutamine: replenishing β-cells in hyperlipidemic T2D mouse model

This study investigates the combined effect of pitavastatin and L-glutamine on glycemic control and β-cell regeneration in a T2D mouse model, finding improved insulin resistance and β-cell regeneration.

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney Precision Medicine Project

The paper describes a pipeline for generating 3D molecular atlases of human kidney biopsies using multi-OMICS and imaging technologies, emphasizing quality control and reproducibility across institutions.

Regulation of heterotopic ossification through local inflammatory monocytes in a mouse model of aberrant wound healing

This study identifies TGFβ1-producing monocytes/macrophages as drivers of heterotopic ossification in a mouse model and shows CD47 activation can reduce HO by modulating these cells.

Environmental chemical diethylhexyl phthalate alters intestinal microbiota community structure and metabolite profile in mice

This study shows DEHP alters gut microbiota composition and metabolite profiles in mice, increasing p-cresol and decreasing butyrate, linked to neurodevelopmental disorders.

Biological Filtering and Substrate Promiscuity Prediction for Annotating Untargeted Metabolomics

The paper introduces EMMA, a computational workflow for untargeted metabolomics annotation, increasing candidate set size and identifying novel metabolites in CHO cells and murine cecal microbiota.

Interactions between species introduce spurious associations in microbiome studies

The paper identifies spurious associations in microbiome studies caused by species interactions and introduces a method to correct for them, revealing key disease-related microbial interactions in inflammatory bowel disease.