A. Schroeder

Cytosolic sodium accumulation is a common danger signal triggering endocytic dysfunction and NLRP3 inflammasome activation

The paper shows that cytosolic sodium accumulation triggers NLRP3 inflammasome activation in response to various danger signals in human macrophages.

Validating a low-cost, open-source, locally manufactured workstation and computational pipeline for automated histopathology evaluation using deep learning

The paper validates a low-cost, open-source workstation and computational pipeline for automated histopathology evaluation using deep learning, showing comparable performance to expensive institutional hardware.

DNase treatment improves viral enrichment in agricultural soil viromes

This study compares DNase-treated and untreated soil viromes, finding DNase improves viral contig assembly and reduces microbial DNA contamination but does not affect ecological patterns.

Bioluminescent Synthetic Cells Communicate with Natural Cells and Self-Activate Light-Responsive Proteins

This paper develops bioluminescent synthetic cells that communicate with natural cells and self-activate light-responsive proteins, enabling in vivo applications without external light sources.

Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases

This study shows that targeting neurons in breast cancer tumors with bupivacaine nanoparticles reduces cancer progression and metastases by inhibiting nerve-to-cancer signaling.

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney Precision Medicine Project

The paper describes a pipeline for generating 3D molecular atlases of human kidney biopsies using multi-OMICS and imaging technologies, emphasizing quality control and reproducibility across institutions.

Chemotherapeutic Nanoparticles Accumulate in the Female Reproductive System during Ovulation Affecting Fertility and Anticancer Activity

This study shows that nanoparticle accumulation in the female reproductive system increases during ovulation, affecting fertility and cancer treatment outcomes.

Evidence for non-methanogenic metabolisms in globally distributed archaeal clades basal to the Methanomassiliicoccales

This study shows that Thermoplasmata archaea lack methanogenesis genes, suggesting methanogenesis was laterally acquired by Methanomassiliicoccales, and identifies new Thermoplasmata lineages with diverse metabolic capabilities.