Longitudinal analysis of a dietary mouse model of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)
M. M. Saenz, J. C. McDonough, E. Bloom-Saldana…·L. S. Trevino
This study tracks histopathological, biochemical, transcriptomic, and microbiome changes in mice fed a NASH-promoting diet over 30 weeks, revealing progressive NAFLD development and immune/xenobiotic gene expression changes.