E. C. Andersen

Direct inference of the distribution of fitness effects of spontaneous mutations from recombinant inbred C. elegans mutation accumulation lines

This study infers the distribution of fitness effects of mutations in C. elegans using recombinant inbred lines, finding that positive effects are common but LD can skew results.

Natural genetic variation in the pheromone production of C. elegans

The paper identifies genetic factors influencing ascaroside pheromone variation in C. elegans using metabolomic and genomic analysis.

C. elegans toxicant responses vary among genetically diverse individuals

This study shows that genetic diversity in C. elegans strains leads to varying toxicant responses, highlighting the need for genetically diverse strains in toxicological screening.

Local adaptation and spatiotemporal patterns of genetic diversity revealed by repeated sampling of Caenorhabditis elegans across the Hawaiian Islands

This study samples C. elegans across Hawaii over three years, sequenced their genomes, and found seven genetic groups and 18 regions linked to local adaptation.

Long-Term Metabolomics Reference Material

The paper introduces IBAT, a method to create stable reference materials for metabolomics, and demonstrates its application in E. coli and C. elegans, showing significant variance from pre-analytical steps.

Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans

The study shows that differences in mutation spectra between lab and natural C. elegans populations are due to mononucleotide repeat mutability, not oxidative stress.

The distribution of mutational effects on fitness in Caenorhabditis elegans inferred from standing genetic variation

This study estimates the distribution of fitness effects from standing genetic variation in C. elegans and shows how self-fertilization and population structure bias DFE inferences.

Selfing is the safest sex for Caenorhabditis tropicalis

This study investigates the mating system of C. tropicalis, finding that selfing reduces outbreeding depression caused by gene drive elements.

Balancing selection maintains hyper-divergent haplotypes in C. elegans

The paper shows that balancing selection maintains genetic diversity in hyper-divergent regions of C. elegans, enabling adaptation despite selfing.

Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations

The paper samples Hawaiian C. elegans strains, revealing high genetic diversity and admixture with global populations, suggesting ancestral diversity preserved in Hawaii.

Selection and gene flow shape niche-associated copy-number variation of pheromone receptor genes

The paper shows that copy-number variation of pheromone receptor genes in C. elegans is shaped by selection and gene flow, contributing to differences in pheromone responses across habitats.