Xist-seeded nucleation sites form local concentration gradients of silencing proteins to inactivate the X-chromosome
Y. Markaki, J. G. Chong, C. Luong, S. Y. X. Tan, Y. Wang, E. C. Jacobson, D. Maestrini, I. Dror, B. A. Mistry, J. Schoeneberg, A. Banerjee, M. Guttman, T. Chou, K. Plath
This study identifies Xist-seeded nucleation sites that create local concentration gradients of silencing proteins, leading to X-chromosome inactivation through macromolecular crowding.
bioRxiv · Nov 22, 2020Cell Biology