Cell BiologybioRxiv
Xist-seeded nucleation sites form local concentration gradients of silencing proteins to inactivate the X-chromosome
Y. Markaki, J. G. Chong, C. Luong…·K. Plath
This study identifies Xist-seeded nucleation sites that create local concentration gradients of silencing proteins, leading to X-chromosome inactivation through macromolecular crowding.