Author

E. C. Wheeler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. J. E. Martin· 1 shared D. Tataru· 1 shared E. J. Sabrowsky· 1 shared E. M. Langholt· 1 shared J. A. MacLean· 1 shared J. C. Jann· 1 shared J. F. Davis· 1 shared J. Taylor· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

B. J. E. Martin

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3 papers

Recent·Most cited

Spatially and temporally varying selection influence species boundaries in two sympatric Mimulus

D. Tataru, E. C. Wheeler, K. G. Ferris

The paper examines how spatial and temporal selection influences divergence between two Mimulus species under varying water availability conditions.

bioRxiv · Dec 7, 2022 · PreprintEvolutionary Biology

Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS/AML

E. C. Wheeler, B. J. E. Martin, W. C. Doyle, R. A. Gorelov, M. Donahue, J. C. Jann, O. Abdel-Wahab, J. Taylor, M. Seiler, S. Buonamici, R. Belizaire, K. Adelman, Z. Tothova

The paper shows SF3B1 splicing modulators impair DNA damage response in cohesin-mutant MDS/AML, leading to increased sensitivity to PARP inhibitors and chemotherapy.

bioRxiv · Sep 26, 2022Cancer Biology

Vapor cannabis exposure generationally affects male reproductive functions in mice

M. Shi, E. M. Langholt, L. C. Butler, M. E. Harvey, E. C. Wheeler, L. Zhao, J. A. MacLean, Y. Oh, E. J. Sabrowsky, S. Yu, S. A. Watson, J. F. Davis, K. Hayashi

This study shows that cannabis vapor exposure in adult male mice reduces sperm count and motility in F0 and F1 generations but not F2, and disrupts spermatogenesis and DNA methylation in F1 testes.

bioRxiv · Aug 22, 2021Pharmacology & Toxicology