The paper identifies that transcriptional repression via BET inhibition and upregulation of NRMKS genes maintains pluripotency in diapause ES cells by suppressing MAP kinase signaling.

bioRxiv · Dec 17, 2023 · PreprintCell Biology

Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS/AML

E. C. Wheeler, B. J. E. Martin, W. C. Doyle, R. A. Gorelov, M. Donahue, J. C. Jann, O. Abdel-Wahab, J. Taylor, M. Seiler, S. Buonamici, R. Belizaire, K. Adelman, Z. Tothova

The paper shows SF3B1 splicing modulators impair DNA damage response in cohesin-mutant MDS/AML, leading to increased sensitivity to PARP inhibitors and chemotherapy.

bioRxiv · Sep 26, 2022Cancer Biology

CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts

M. L. Insco, B. J. Abraham, S. J. Dubbury, S. Dust, C. Wu, K. Y. Chen, D. Liu, C. G. Ludwig, S. Bellaousov, T. Fabo, T. Henriques, K. Adelman, M. Geyer, P. A. Sharp, R. A. Young, , L. I. Zon

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.

bioRxiv · Nov 5, 2019Biophysics