Metabolic connections between folate and peptidoglycan pathways in Pseudomonas aeruginosa inform rational design of a dual-action inhibitor
L. N. Yaeger, D. Sycantha, P. Luong, S. Shekarriz, O. Goncalves, A. Dobrin, M. R. Ranieri, R. P. Lamers, H. Harvey, G. C. diCenzo, M. G. Surette, J.-P. Cote, J. Magolan, L. L. Burrows
This study identifies metabolic links between folate and peptidoglycan pathways in Pseudomonas aeruginosa and uses these insights to design a dual-action inhibitor that overcomes antibiotic resistance.
bioRxiv · Nov 22, 2023 · PreprintMicrobiology