ImmunologybioRxivPreprint
Dectin-1 limits central nervous system autoimmunity through a non-canonical pathway
M. E. Deerhake, K. Danzaki, M. Inoue…·M. L. Shinohara
This study shows Dectin-1 protects against CNS autoimmunity through a non-canonical pathway independent of Card9, promoting neuroprotective molecules like Osm in myeloid cells and reducing EAE severity via astrocytic OsmR signaling.
DOI 10.1101/2020.05.06.080481