Author

W. E. Barclay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. E. Deerhake· 2 shared M. Inoue· 2 shared M. L. Shinohara· 2 shared N. Aggarwal· 2 shared T. Nonaka· 2 shared A. Contreras· 1 shared D. DiPalma· 1 shared D. Wiest· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

M. E. Deerhake

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintDec 3, 2021

Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection pre-T cells

J. J. Ratiu, W. E. Barclay, Q. Wang…·Y. Zhuang

This study identifies Zfp335 as a transcription factor that regulates survival of post-β-selection DN4 thymocytes by suppressing cGAS/STING-dependent apoptosis.

DOI 10.1101/2021.12.03.471158

mouseexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 3, 2021

AIM2 inflammasome activation in astrocytes occurs during the late phase of EAE

W. E. Barclay, M. E. Deerhake, M. Inoue…·M. L. Shinohara

This study identifies AIM2 inflammasome activation in astrocytes during the late phase of EAE, distinct from traditional inflammasome-mediated inflammation.

DOI 10.1101/2021.10.03.462457

mouseexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintMay 6, 2020

Dectin-1 limits central nervous system autoimmunity through a non-canonical pathway

M. E. Deerhake, K. Danzaki, M. Inoue…·M. L. Shinohara

This study shows Dectin-1 protects against CNS autoimmunity through a non-canonical pathway independent of Card9, promoting neuroprotective molecules like Osm in myeloid cells and reducing EAE severity via astrocytic OsmR signaling.

DOI 10.1101/2020.05.06.080481

mouseproteomics

𝕏 PostBluesky