Enhancer landscape of lung neuroendocrine tumors reveals regulatory and developmental signatures with potential theranostic implications
E. Davis, S. Avniel-Polak, S. Abu-Kamel, I. Antman, T. Saadoun, C. Brim, A. Bel-Ange, K. Atlan, T. Tzur, F. Abu-Akar, O. Wald, U. Izhar, M. Hecht, S. Grozinsky-Glasberg, Y. Drier
This study identifies three regulatory subtypes of lung neuroendocrine tumors through ChIP-seq and RNA-seq, revealing distinct transcription factor signatures and therapeutic vulnerabilities.
bioRxiv · Nov 17, 2023Cancer Biology