Author

A. J. Vila

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

R. A. Bonomo· 5 shared M. S. Ramirez· 3 shared C. Li· 2 shared C. Pimentel· 2 shared C. Razo-Gutierrez· 2 shared L. J. Gonzalez· 2 shared M. Tolmasky· 2 shared R. Sieira· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersMicrobiology

R. A. Bonomo

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase

Z. Zhao, X. Shen, S. Chen, J. Gu, H. Wang, M. F. Mojica, M. Samanta, D. Bhowmik, A. J. Vila, R. A. Bonomo, S. Haider

The paper investigates how gating interactions between loops in the L1 metallo-β-lactamase affect active site conformational changes and identifies key residues critical for enzyme activity.

bioRxiv · Oct 25, 2022Biophysics

The mitochondrial Cu+ transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro

C. McCann, M. Quinteros, I. Adelugba, M. N. Morgada, A. R. Castelblanco, E. Davis, A. Lanzirotti, S. J. Hainer, A. J. Vila, J. G. Navea, T. PADILLA-BENAVIDES

This study identifies PiC2 as a copper transporter regulated by MTF1, essential for skeletal muscle myoblast proliferation and differentiation by delivering copper to COX.

bioRxiv · Sep 5, 2022Cell Biology

Impact of Human Serum Proteins on Susceptibility of Acinetobacter baumannii to Cefiderocol: role of iron transport

C. Le, C. Pimentel, F. Pasteran, M. R. Tuttobene, T. Subils, J. Escalante, B. Nishimura, S. Arriaga, A. Carranza, A. J. Vila, A. Corso, L. A. Actis, M. Tolmasky, R. A. Bonomo, M. S. Ramirez

The paper shows that human serum and its components increase Acinetobacter baumannii resistance to cefiderocol by altering iron uptake and beta-lactam resistance genes.

bioRxiv · Aug 18, 2021Microbiology

Development of antibiotic resistance reveals diverse evolutionary pathways to face the complex and dynamic environment of a long-term treated patient

C. A. Colque, P. E. Tomatis, A. G. Albarracin Orio, G. Dotta, D. M. Moreno, L. G. Hedemann, R. A. Hickman, L. M. Sommer, S. Feliziani, A. M. Moyano, R. A. Bonomo, H. K. Johansen, S. Molin, A. J. Vila, A. M. Smania

This study tracks the long-term evolution of antibiotic-resistant Pseudomonas aeruginosa in a cystic fibrosis patient, revealing diverse genetic changes that enhance resistance to multiple cephalosporins.

bioRxiv · May 14, 2021 · PreprintMicrobiology

Cerebrospinal fluid (CSF) boosts metabolism and virulence expression factors in Acinetobacter baumannii

J. Martinez, C. Razo-Gutierrez, C. Li, R. Courville, C. Pimentel, C. Liu, S. Fung, A. J. Vila, P. Shahrestani, V. Jimenez, M. Tolmasky, S. A. Becka, K. M. Papp-Wallace, R. A. Bonomo, A. Soler, , M. S. Ramirez

This study shows that cerebrospinal fluid (CSF) enhances virulence factor expression and metabolic processes in low-virulence Acinetobacter baumannii strains.

Scientific Reports · Feb 26, 2021Peer-reviewedMicrobiology

Molecular Bases of the Membrane Association Mechanism Potentiating Antibiotic Resistance by New Delhi Metallo--Lactamase 1

A. Prunotto, G. Bahr, L. J. Gonzalez, A. J. Vila, M. Dal Peraro

This study identifies key residues in NDM-1 that mediate its membrane association, providing targets for combating antibiotic resistance.

bioRxiv · Jun 1, 2020Biochemistry

The H-NS regulator plays a role in the stress induced by carbapenemase expression in Acinetobacter baumannii

F. Huang, N. Fitchett, C. Razo-Gutierrez, C. Li, G. Ra, C. Lopez, L. J. Gonzalez, R. Sieira, A. J. Vila, R. A. Bonomo, M. S. Ramirez

This study shows H-NS alleviates envelope stress from MBL expression and DNA-damaging agents in A. baumannii, linking it to stress response and carbapenem resistance.

bioRxiv · May 18, 2020Microbiology