Author

C. McCann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Cell Biology· 2 Pathology· 1 Zoology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:development & morphogenesis· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:non-human primate· 2

Frequent Co-Authors

C. Olmstead· 2 shared D. B. Longley· 2 shared D. G. Diel· 2 shared D. McAloose· 2 shared E. M. Kerr· 2 shared J. M. Sykes· 2 shared K. Ingerman· 2 shared K. Terio· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersZoology

C. Olmstead

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The mitochondrial Cu+ transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro

C. McCann, M. Quinteros, I. Adelugba, M. N. Morgada, A. R. Castelblanco, E. Davis, A. Lanzirotti, S. J. Hainer, A. J. Vila, J. G. Navea, T. PADILLA-BENAVIDES

This study identifies PiC2 as a copper transporter regulated by MTF1, essential for skeletal muscle myoblast proliferation and differentiation by delivering copper to COX.

bioRxiv · Sep 5, 2022Cell Biology

Synchronisation of apical constriction and cell cycle progression is a conserved behaviour of pseudostratified neuroepithelia informed by their tissue geometry

I. Ampartzidis, C. Efstathiou, F. Paonessa, E. M. Thompson, T. Wilson, C. McCann, N. Greene, A. Copp, F. J. Livesey, N. Elvassore, G. G. Giobbe, P. De Coppi, E. Maniou, G. L. Galea

This study shows that neuroepithelial cells synchronize apical constriction with cell cycle progression, but the timing of constriction is influenced by tissue geometry in different regions of the neural tube.

bioRxiv · Jun 15, 2022Cell Biology

Clinical positioning of the IAP antagonist tolinapant (ASTX660) in colorectal cancer

D. B. Longley, N. T. Crawford, K. J. Stott, T. Sessler, C. McCann, W. McDaid, C. Latimer, J. Fox, J. M. Munck, T. Smyth, A. Shah, V. Martins, M. Lawler, P. D. Dunne, E. M. Kerr, , V. M. Coyle

This study shows tolinapant, an IAP inhibitor, enhances chemotherapy-induced apoptosis in colorectal cancer by modulating FLIP and HDACs, suggesting its clinical use in poor prognosis MSS CRC with elevated cIAP1/2.

bioRxiv · Nov 20, 2020Cancer Biology

SARS-CoV-2 Infection And Longitudinal Fecal Screening In Malayan Tigers (Panthera tigris jacksoni), Amur Tigers (Panthera tigris altaica), And African Lions (Panthera leo krugeri) At The Bronx Zoo, New York, USA

S. L. Bartlett, D. G. Diel, L. Wang, S. Zec, M. Laverack, M. Martins, L. C. Caserta, M. L. Killian, K. Terio, C. Olmstead, M. A. Delaney, T. Stokol, M. Ivancic, M. Jenkins-Moore, K. Ingerman, , P. P. Calle

This paper reports the first known natural SARS-CoV-2 transmission from humans to animals in the USA, documenting clinical signs, diagnostic findings, and prolonged fecal RNA shedding in tigers and lions.

bioRxiv · Aug 14, 2020Zoology

From people to Panthera: Natural SARS-CoV-2 infection in tigers and lions at the Bronx Zoo

D. McAloose, M. Laverack, L. Wang, M. L. Killian, L. C. Caserta, F. Yuan, P. K. Mitchell, K. Queen, M. R. Mauldin, B. D. Cronk, S. L. Bartlett, J. M. Sykes, S. Zec, T. Stokol, K. Ingerman, , D. G. Diel

The paper reports the first natural SARS-CoV-2 infections in tigers and lions at the Bronx Zoo, identifying two distinct viral strains and suggesting human-to-animal transmission.

bioRxiv · Jul 22, 2020Pathology

FLIP(L) determines p53 induced life or death

A. Lees, A. J. McIntyre, F. Falcone, N. T. Crawford, C. McCann, G. P. Quinn, J. Z. Roberts, T. Sessler, P. F. Gallagher, K. McAllister, K. McLaughlin, W. L. Allen, C. Holohan, L. J. Egan, A. E. Ryan, , S. S. McDade

This study identifies FLIP(L) as a p53 target that determines cell fate by promoting cell cycle arrest and inhibiting apoptosis.

bioRxiv · Nov 28, 2019 · PreprintCancer Biology