E. Debold

Modeling Thick Filament Activation Suggests a Molecular Basis for Force Depression

The paper develops a multiscale model of muscle contraction that explains force depression by integrating molecular and cellular measurements from rabbit psoas muscle.

Positional isomers of a non-nucleoside substrate differentially affect myosin function

This study shows that positional isomers of a synthetic non-nucleoside triphosphate can differentially control myosin function by altering force and motion generation without changing myosin structure.