B. Scott

A cross-species framework for investigating perceptual evidence accumulation

This paper develops a cross-species evidence accumulation task to compare perceptual decision-making in humans, rats, and mice, finding similar strategies but species-specific priorities in speed, accuracy, and reward optimization.

Modeling Thick Filament Activation Suggests a Molecular Basis for Force Depression

The paper develops a multiscale model of muscle contraction that explains force depression by integrating molecular and cellular measurements from rabbit psoas muscle.

Single Molecule Mechanics and Kinetics of Cardiac Myosin Interacting with Regulated Thin Filaments

This study investigates how thin filament regulatory proteins affect the mechanics and kinetics of cardiac myosin using single-molecule techniques, finding no significant impact at physiological ATP concentrations but some effects at low ATP.

Performance of the cobas(R) HBV RNA Automated Investigational Assay for the Detection and Quantification of Circulating HBV RNA in Chronic HBV Patients

This study evaluates the cobas(R) HBV RNA assay's performance in detecting and quantifying circulating HBV RNA in chronic HBV patients, showing high sensitivity and minimal interference from HBV DNA.

Expression of extracellular Hsp90 is a molecular signature of T cell activation, providing a means to image and target T Cell activation in autoimmune disease

This study identifies eHsp90 as a marker of T cell activation, showing its upregulation in autoimmune diseases and demonstrating the efficacy of an inhibitor in delaying disease progression.

Epichloe festucae in mutualistic association with Lolium perenne suppresses host apoplastic cysteine protease activity

This study identifies and characterizes apoplastic cysteine proteases in Lolium perenne and shows that mutualistic Epichloe festucae suppresses their activity through potential inhibitors like LpCys1.

A homologue of the mammalian tumour suppressor protein PTEN is a functional lipid phosphatase and required for chemotaxis in filamentous fungi

This study identifies TepA, a fungal homologue of PTEN, as a functional lipid phosphatase required for chemotaxis in filamentous fungi.

Positional isomers of a non-nucleoside substrate differentially affect myosin function

This study shows that positional isomers of a synthetic non-nucleoside triphosphate can differentially control myosin function by altering force and motion generation without changing myosin structure.

Reprogramming of the apoplast metabolome of Lolium perenne upon infection with the mutualistic symbiont Epichloë festucae

The paper investigates changes in the apoplast metabolome of Lolium perenne infected with Epichloë festucae, identifying novel metabolites and validating methods for their detection.

Aerosolized TLR Agonists Suppress Acute Sendai Virus Lung Infection and Chronic Airway Disease in Mice

The paper shows that aerosolized TLR agonists reduce Sendai virus lung burden and chronic asthma-like disease in mice by suppressing inflammation and IL-33 production.