ImmunologybioRxiv
ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.
R. de Reuver, E. Dierick, B. Wiernicki…·J. Maelfait
This study shows that ADAR1's interaction with Z-RNA reduces A-to-I editing of self-dsRNA, leading to MDA5-dependent immune activation and AGS in mutant cells and mice.