E. Eyras

A comprehensive single-cell expression atlas of human AML leukemia-initiating cells unravels the contribution of HIF pathway and its therapeutic potential

The paper creates a single-cell atlas of AML leukemia-initiating cells and shows that targeting the HIF pathway enhances chemotherapy effectiveness against these cells.

A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1

The paper identifies a convergent malignant phenotype in infant B-ALL linked to SRRM1 upregulation and splicing alterations, independent of gene fusions.

Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome

This study shows that JZL184 treatment improves social, cognitive, and cardiac phenotypes in a mouse model of Williams-Beuren syndrome by modulating the endocannabinoid system.

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice

Reduced PAX5 function in mice leads to uncommitted B cell development and B-ALL with secondary mutations in Jak3 and Ptpn11.

Combined analysis of genome sequencing and RNA-motifs reveals novel damaging non-coding mutations in human tumors

The paper identifies novel damaging non-coding mutations in human tumors by analyzing genome sequencing and RNA-motifs using a new method called MIRA.

The functional impact of alternative splicing in cancer

The paper analyzes alternative splicing changes in cancer samples to identify their functional impact and potential role in tumorigenesis, finding a negative correlation with somatic mutations and proposing some as oncogenic processes.