Author

E. Fodor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Research Focus:protein structure prediction· 2 Organism:virus· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

J. R. Keown· 3 shared D. L. Bauer· 2 shared H. Fan· 2 shared J. Grimes· 2 shared J. M. Grimes· 2 shared L. Carrique· 2 shared A. Baazaoui· 1 shared A. J. te Velthuis· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

J. R. Keown

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Structural and functional characterisation of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA Polymerase II

J. Keown, A. Baazaoui, M. Sebesta, R. Stefl, L. Carrique, E. Fodor, J. Grimes

This study characterizes the structural and functional interaction between influenza A virus RNA polymerase and host RNA Polymerase II CTD, identifying key residues and their roles in transcription and replication.

bioRxiv · Nov 29, 2023 · PreprintMicrobiology

Structural Characterization of the Full-length Hantaan Virus Polymerase

J. R. Keown, L. Carrique, B. Nilsson-payant, E. Fodor, J. M. Grimes

This study characterizes the structure of the full-length Hantaan virus polymerase using cryo-EM, revealing conformational states relevant to replication and transcription.

bioRxiv · Jun 9, 2023 · PreprintBiochemistry

Identification of guanylyltransferase activity in the SARS-CoV-2 RNA polymerase

A. P. Walker, H. Fan, J. R. Keown, J. Grimes, E. Fodor

This paper identifies the guanylyltransferase activity in SARS-CoV-2 RNA polymerase and shows remdesivir triphosphate inhibits both GTase and polymerase functions.

bioRxiv · Mar 17, 2021 · PreprintMicrobiology

Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases

A. Walker, H. Fan, J. R. Keown, V. Margitich, J. M. Grimes, E. Fodor, A. J. te Velthuis

This paper shows enisamium and its metabolite VR17-04 inhibit RNA polymerases of influenza A and SARS-CoV-2, with VR17-04 matching remdesivir's efficacy against SARS-CoV-2.

bioRxiv · Apr 21, 2020 · PreprintMicrobiology

Mini viral RNAs act as innate immune agonists during influenza virus infection

A. te Velthuis, J. Long, D. L. Bauer, R. Fan, H.-L. Yen, J. Sharps, J. Siegers, M. Killip, H. French, M. J. Oliva-Martin, R. Randall, E. de Wit, D. van Riel, L. Poon, E. Fodor

This study identifies mini viral RNAs (mvRNAs) as activators of the RIG-I sensor, leading to interferon-beta expression and cytokine storm during influenza virus infection.

bioRxiv · Aug 6, 2018Microbiology

The structure of the influenza A virus genome

B. Dadonaite, E. Barilaite, E. Fodor, A. Laederach, D. L. Bauer

This study maps RNA-RNA interactions in influenza A virus genomes, revealing a structured genome and redundant interactions that enable reassortment and packaging selectivity.

bioRxiv · Dec 21, 2017Microbiology

Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage

P. I. Kulcsar, A. Talas, K. Huszar, Z. Ligeti, E. Toth, N. Weinhardt, E. Fodor, E. Welker

The paper develops HeFSpCas9 variants by combining mutations from eSpCas9 and SpCas9-HF1 to improve specificity and cleavage, showing that no single variant is universally optimal.

bioRxiv · Sep 12, 2017Bioengineering