Author

J. M. Grimes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. R. Keown· 3 shared E. Fodor· 2 shared L. Carrique· 2 shared A. J. te Velthuis· 1 shared A. Kotecha· 1 shared A. Walker· 1 shared B. Nilsson-payant· 1 shared C. A. Okolo· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

J. R. Keown

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

BiochemistrybioRxivPreprintJun 9, 2023

Structural Characterization of the Full-length Hantaan Virus Polymerase

J. R. Keown, L. Carrique, B. Nilsson-payant…·J. M. Grimes

This study characterizes the structure of the full-length Hantaan virus polymerase using cryo-EM, revealing conformational states relevant to replication and transcription.

DOI 10.1101/2023.06.09.544421

cryo-EMexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintJun 7, 2020

A high resolution view of an adolescent flavivirus

M. Renner, W. Dejnirattisai, L. Carrique…·J. M. Grimes

This study presents high-resolution cryo-EM structures of immature and mature flaviviruses, revealing structural changes during maturation and the role of pH in conformational rearrangements.

DOI 10.1101/2020.06.07.138669

cryo-EMexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintApr 21, 2020

Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases

A. Walker, H. Fan, J. R. Keown…·A. J. te Velthuis

This paper shows enisamium and its metabolite VR17-04 inhibit RNA polymerases of influenza A and SARS-CoV-2, with VR17-04 matching remdesivir's efficacy against SARS-CoV-2.

DOI 10.1101/2020.04.21.053017

experimental assay

𝕏 PostBluesky

Cell BiologybioRxivJan 13, 2020

Correlative cryo-structured illumination fluorescence microscopy and soft X-ray tomography elucidates reovirus intracellular release pathway

M. Harkiolaki, I. Kounatidis, M. L. Stanifer…·I. M. Dobbie

This study develops a correlative imaging platform combining cryo-SIM and SXT to study reovirus release from intracellular vesicles, revealing novel virus-induced structures.

DOI 10.1016/j.cell.2020.05.051

fluorescence / live-cell microscopymicroscopy & imaging analysis

𝕏 PostBluesky