Author

J. Long

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Plant Biology· 4 Biophysics· 2 Microbiology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Assay:bulk RNA-seq· 6 Research Focus:host-pathogen & immune response· 6 Organism:human· 6 Research Focus:cell signaling & trafficking· 5 Research Focus:cell type annotation· 5 Approach:statistical model· 4 Research Focus:differential expression· 3

Frequent Co-Authors

A. Damm· 2 shared B. Molloy· 2 shared B. Senatori· 2 shared C. He· 2 shared C. Pellegrin· 2 shared D. S. Shin· 2 shared P. Vieira· 2 shared S. Eves-van den Akker· 2 shared

Activity by Year

2017-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPathology

A. Damm

Mutual co-authors in cluster

Author profile →

16 papers

Recent·Most cited

The SUbventral-Gland master Regulator (SUGR) of nematode virulence

C. Pellegrin, A. Damm, A. L. Sperling, B. Molloy, D. S. Shin, J. Long, P. Brett, A. D.-T. Bravo, S. J. Lynch, B. Senatori, P. Vieira, J. Mejias, A. Kumar, R. E. Masonbrink, T. R. Maier, , S. Eves-van den Akker

This paper identifies SUGR1 as a master regulator in nematodes that orchestrates effector production, essential for host entry and parasitism, and shows blocking SUGR1 prevents parasitism.

bioRxiv · Jan 22, 2024 · PreprintPathology

The origin, deployment, and evolution of a plant-parasitic nematode effectorome

B. Molloy, D. S. Shin, J. Long, C. Pellegrin, B. Senatori, P. Vieira, P. J. Thorpe, A. Damm, M. Ahmad, K. Vermeulen, L. Derevnina, S. Wei, A. Sperling, E. Reyes Estevez, S. Bruty, , S. Eves-van den Akker

This study identifies and characterizes the effectorome of the plant-parasitic nematode Heterodera schachtii, revealing 659 effector gene loci and providing insights into their origin, deployment, and evolution.

bioRxiv · Jan 5, 2024Plant Biology

Ikzf1 association with Foxp3 for Foxp3-dependent gene repression in Treg cells: induction of autoimmunity and tumor immunity by disrupting the association

K. Ichiyama, J. Long, Y. Kobayashi, Y. Horita, T. Kinoshita, Y. Nakamura, C. Kominami, K. Georgopoulos, S. Sakaguchi

This study shows that Ikzf1 associates with Foxp3 to repress genes in Treg cells, and disrupting this association leads to autoimmunity and enhanced tumor immunity.

bioRxiv · Aug 12, 2023 · PreprintImmunology

A method for rapid nanobody screening with no bias of the library diversity

L. He, Z. Tao, X. Zhao, H. Wang, J. Zhang, G. Jiang, B. Yu, Y. Chen, M. Zhu, J. Long, L. Yin, X. Zhang, M. Liu

This paper introduces a method for rapid nanobody screening that preserves library diversity without subcloning or amplification bias, producing functional nanobodies against DR5 and Pfu DNA polymerase.

bioRxiv · Feb 15, 2023Biochemistry

Monkeypox virus quadrivalent mRNA vaccine induces antibody responses and cellular immunity and protects mice against Vaccinia virus

Y. Sang, Z. Zhang, F. Liu, H. Lu, C. Yu, H. Sun, J. Long, Y. Cao, J. Mai, X. Wang, J. Fang, Y. Wang, W. Huang, J. Yang, S. Wang

This study develops two quadrivalent mRNA vaccines against monkeypox virus and shows they induce antibodies, cellular immunity, and protection against Vaccinia virus in mice.

bioRxiv · Nov 22, 2022 · PreprintImmunology

Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol

A. G. CASHIKAR, D. T. Rios, D. Timm, J. Romero, J. Long, X. Han, D. Holtzman, S. M. Paul

This study shows that 25-hydroxycholesterol from microglia alters astrocyte lipid metabolism and ApoE secretion through mechanisms involving LXRs, Abca1, and Cyp7b1.

bioRxiv · May 3, 2022Cell Biology

Dissecting Mutational Allosteric Effects in Alkaline Phosphatases Associated with Different Hypophosphatasia Phenotypes: An Integrative Computational Investigation

F. Xiao, Z. Zhou, X. Song, M. Gan, J. Long, G. Verkhivker, G. Hu

This paper uses computational methods to analyze ALPL mutations in Hypophosphatasia, finding that severe mutations significantly affect allosteric communications and protein stability.

bioRxiv · Jan 24, 2022Biophysics

Lymphoid follicle formation and human vaccination responses recapitulated in an organ-on-a-chip

G. Goyal, P. Prabhala, G. Mahajan, B. Bausk, T. Gilboa, L. Xie, Y. Zhai, R. Lazarovits, A. Mansour, M. S. Kim, D. Curran, J. Long, S. Sharma, L. Cohen, O. Levy, , D. E. Ingber

This paper demonstrates the formation of lymphoid follicles in a human organ-on-a-chip model and shows improved vaccine responses compared to 2D cultures.

bioRxiv · Apr 28, 2021 · PreprintImmunology

Spatial modulation of individual behaviors enables collective decision-making during bacterial group migration

Y. Bai, C. He, J. Long, X. Li, X. Fu

The paper studies bacterial group migration and finds that spatially modulated individual behaviors enable coherent collective movement without complex computation.

bioRxiv · Feb 17, 2021Microbiology

Nurse cell-derived small RNAs define paternal epigenetic inheritance in Arabidopsis

J. Long, J. Walker, W. She, B. Aldridge, H. Gao, S. Deans, X. Feng

The paper identifies nurse cell-derived small RNAs that establish paternal epigenetic inheritance in Arabidopsis by directing germline DNA methylation.

bioRxiv · Jan 25, 2021Plant Biology

Multiplexed Imaging Analysis of the Tumor-Immune Microenvironment Reveals Predictors of Outcome in Triple-Negative Breast Cancer

A. N. Patwa, R. Yamashita, J. Long, M. Angelo, L. Keren, D. Rubin

The paper uses multiplexed ion-beam imaging to analyze the tumor-immune microenvironment in triple-negative breast cancer, identifying immunological predictors of patient outcomes.

bioRxiv · Jan 6, 2021Cancer Biology

Momilactone B inhibits Arabidopsis growth and development via disruption of ABA and auxin signaling

J. Wu, J. Long, X. Lin, Z. Chang, S. R. Baerson, C. Ding, X. Wu, Z. Pan, Y. Song, R. Zeng

Momilactone B inhibits Arabidopsis growth and development by disrupting ABA and auxin signaling, highlighting the role of phytohormones in allelopathic responses.

bioRxiv · Sep 30, 2020 · PreprintPlant Biology

Overexpressing CsGH3.1 and CsGH3.1L reduces susceptibility to Xanthomonas citri subsp. citri by repressing auxin signaling in citrus (Citrus sinensis Osbeck)

X. Zou, J. Long, K. Zhao, A. Peng, M. Chen, Q. Long, Y. He, S. Chen

This study shows overexpressing CsGH3.1 and CsGH3.1L in citrus reduces susceptibility to Xcc by repressing auxin signaling and enhancing defense responses.

bioRxiv · Jul 9, 2019Plant Biology

Mini viral RNAs act as innate immune agonists during influenza virus infection

A. te Velthuis, J. Long, D. L. Bauer, R. Fan, H.-L. Yen, J. Sharps, J. Siegers, M. Killip, H. French, M. J. Oliva-Martin, R. Randall, E. de Wit, D. van Riel, L. Poon, E. Fodor

This study identifies mini viral RNAs (mvRNAs) as activators of the RIG-I sensor, leading to interferon-beta expression and cytokine storm during influenza virus infection.

bioRxiv · Aug 6, 2018Microbiology

Spatial Self-Organization Resolves Conflicts Between Individuality and Collective Migration

X. Fu, S. Kato, J. Long, H. H. Mattingly, C. He, D. C. Vural, S. W. Zucker, T. Emonet

The paper studies how clonal Escherichia coli cells maintain collective migration despite individual differences in chemotactic ability through spontaneous spatial sorting within the moving band.

bioRxiv · Apr 5, 2018Biophysics

Murine Glomerular Transcriptome Links Endothelial Cell-Specific Molecule-1 Deficiency With Susceptibility To Diabetic Nephropathy

X. Zheng, F. Soroush, J. Long, E. T. Hall, P. K. Adishesha, S. Bhattacharya, M. F. Kiani, V. Bhalla

This study identifies Esm-1 as a glomerular biomarker for diabetic nephropathy susceptibility, showing it inversely correlates with disease risk and inhibits leukocyte infiltration.

bioRxiv · May 27, 2017Immunology