D. van Riel

Dissecting MPXV neurotropism and host antiviral signaling using human stem cell-based models

This study investigates MPXV neurotropism and antiviral signaling in CNS cells using human stem cell-derived models, finding that glial cells are more susceptible and exhibit reduced type I IFN responses.

The potential role of human immune cells in the systemic dissemination of enterovirus-D68

This study investigates how immune cells contribute to the systemic spread of EV-D68, showing that B cells and dendritic cells can be infected and facilitate virus dissemination.

The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells

This study shows that endothelial cells are abortively infected by influenza A virus and contribute to systemic inflammation through increased cytokine secretion in co-cultures with infected epithelial cells.

Differences in neuroinflammation in the olfactory bulb between D614G, Delta and Omicron BA.1 SARS-CoV-2 variants in the hamster model

The paper compares neuroinflammation in the olfactory bulb of hamsters infected with D614G, Delta, and Omicron BA.1 SARS-CoV-2 variants, finding differences in neuroinvasion and neurovirulence.

Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters

This study inoculates Syrian golden hamsters with SARS-CoV-2 Omicron BA.1 to compare its pathogenicity and viral shedding to Delta, finding reduced clinical signs and viral shedding but still pneumonia, with pre-existing immunity offering protection.

Replication kinetic, cell tropism and associated immune responses in SARS-CoV-2 and H5N1 virus infected human iPSC derived neural models

This study compares SARS-CoV-2 and H5N1 virus replication, cell tropism, and immune responses in human iPSC-derived neural cultures, finding sparse SARS-CoV-2 infection with immune activation versus efficient H5N1 replication.

Temporal kinetics of RNAemia and associated systemic cytokines in hospitalized COVID-19 patients

This study examines the temporal changes in viral RNA and cytokine levels in hospitalized COVID-19 patients, finding differences in RNAemia duration and cytokine associations with disease severity.

Mini viral RNAs act as innate immune agonists during influenza virus infection

This study identifies mini viral RNAs (mvRNAs) as activators of the RIG-I sensor, leading to interferon-beta expression and cytokine storm during influenza virus infection.